Substance p regulates chemokine production in leukocytes implications in the pathogenesis of acute pancreatitis and associated lung injury

... infiltrating leukocytes (neutrophils and macrophages) in the pancreas are the main sources of chemokine production in caerulein-induced acute pancreatitis in mice and the alveolar macrophages, epithelial ... partially associated with the suppression of SP expression in the pancreas and lungs in the condition (Lau and Bhatia, 2006) Despite the cl...

Ngày tải lên: 11/09/2015, 09:09

... components The profile was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by ... multiple MMP mRNAs by S aureus in human dermal and synovial fibroblasts Multiple MMP mRNA profile in dermal and synovial fibroblasts in respo...

Ngày tải lên: 09/08/2014, 08:23

... Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications Journal of Hematology & Oncology 2011 4:13 Submit your next manuscript ... The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and be...

Ngày tải lên: 10/08/2014, 21:23

... abnormalities in systemic lupus erythematosus Curr Immunol Rev 2005, 1:61-67 Perl A: Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren’s syndrome ... regulates mammalian target of rapamycin activity and TCRζ expression in SLE The mammalian target of rapamycin (mTOR) is a serine/ threonine protein kinase a...

Ngày tải lên: 12/08/2014, 14:22

... lipids, resulting in changes in fluidity of the bilayer Additionally, there is increased ion permeability, inactivation of membrane enzymes and receptors, and covalent cross-linking of lipid Once ... these erythrocytes Role of white blood cells in oxidant production in acute chest syndrome Although SCD is a genetic disorder of the hemoglobin molecule, there is a...

Ngày tải lên: 12/08/2014, 18:20

... 1.2 The Nuclear Receptor Co- repressor (N- CoR), a component of the transcriptional repression machinery and its role in AML pathogenesis 1.2.1 The importance of the transcription machinery in the ... these factors become key initiators of AML pathogenesis 1.2.2 The Nuclear Receptor Co- Repressor (N- CoR) The nuclear receptor co- re...

Ngày tải lên: 09/09/2015, 18:55

... polyglutamine-expanded huntingtin [18], the tumor suppressor Synoviolin is involved in the degradation of nicastrin gene p53 [19] and Parkin-associated endothelin receptor-like receptor [20] In this ... whether Synoviolin is involved in the degradation of PS cofactors using synoviolin-null cells, as PS cofactors undergo the ubiquitin ⁄ proteasome pathway We r...

Ngày tải lên: 23/03/2014, 04:20

... inhibition of 23 24 25 intervertebral disc degeneration Int J Exp Pathol 2006, 87:17-28 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc ... cells by the action of TNF-α Discussion This study investigates the effect of the pro-inflammatory cytokines IL-1β and TNF-α on catabolic gene expre...

Ngày tải lên: 09/08/2014, 14:20

... expression < /b> Finally, we examined the effects < /b> of < /b> the chemokines < /b> on < /b> the expression < /b> of < /b> the cell surface molecules ICOSL, BAFF-R and < /b> TACI by peripheral blood B cells of < /b> normal donors and < /b> sub- Page of < /b> 11 ... chemokine receptor < /b> expression < /b> by peripheral blood in both normal donors and < /b> subject...

Ngày tải lên: 09/08/2014, 14:22

... number of differences in the N-terminal domain (located on the matrix side) It is likely that the N-terminal domain is involved in protein protein interactions with other hydrophilic domains of neighboring ... chain was established with succinate and glycerol3-phosphate as substrates Complex II activity was determined after addition of succinate, followed by inhibition b...

Ngày tải lên: 19/02/2014, 16:20

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...

Ngày tải lên: 08/03/2014, 08:20

... representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes FadD22, FadD26 ... protein involved in the biosynthesis of PGL-tb in M tuberculosis These data also established that, in contrast to fadD26, f...

Ngày tải lên: 15/03/2014, 11:20

... followed by the blocking of FLS apoptosis FLIP upregulated by MLN51 plays a crucial role in the anti-apoptosis of MH7A cells We examined whether FLIP was involved in the antiapoptosis of MH7A cells ... affect MLN51 and FLIP induction in MH7A cells (Fig 5B), indicating that ERK is unlikely to be involved in the GM-CSF-mediated induction of MLN51 and FLIP...

Ngày tải lên: 23/03/2014, 07:20