Transplantation of mesenchymal stem cells for the treatment of parkinsons disease in a mouse model

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... MPTP, an acute insult initiates an inflammatory reaction that becomes self sustaining after the initiating agent has disappeared The MPTP model of...

Ngày tải lên: 11/09/2015, 09:05

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... source of cells and the potential to derive the cell type of interest together with the possibility to enrich for genetic modifications during the dividing stem cell state 1.1.1 Human pluripotent stem ... stem cells Landmark discoveries of the young field of human stem cell science were the isolation and culture of inner cell mass from hu...

Ngày tải lên: 26/11/2015, 09:54

... article as: Liu et al.: Effects of transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin on experimental stroke in rats Journal of Translational Medicine 2011 9:105 Submit ... result in better therapeutic effects for stroke in rats In this paper, we try to investigate the effects of transplantation with MSCs mod...

Ngày tải lên: 18/06/2014, 19:20

... differentiation of MSCs: Upon induction with adipocyte induction media cells showed adipocyte globules on oil red O staining (D) Osteogenic differentiation of MSCs: Upon induction with osteogenic induction ... http://www.translational-medicine.com/content/9/1/105 Evaluation of neurological function Evaluation of neurological function was performed day and 14 days after transp...

Ngày tải lên: 20/06/2014, 04:20

... 1.5.2.1 Bone marrow stem cells There are most common types of stem cells in bone marrow: (i) hematopoietic stem cells and (ii) mesenchymal stem cells These cell types are believed to be ideal for myocardial ... Stem cells 1.5.1.1 Embryonic stem cells 1.5.1.2 ES cell stem therapy is not ideal for clinical use 1.5.2 Adult stem cells 10 1.5.2.1...

Ngày tải lên: 12/09/2015, 09:42

... antibodies used in 3D immunohistological and CD marker studies Antibody Source Dilution Type I collagen Biodesign International (Kennebunk, ME) 20 μg/ml Type II collagen Biodesign International (Kennebunk, ... dimensional; CD, cluster of differentiation plastic adherence and lineage specific differentiation satisfy the standard criteria suggested for defining mesenchymal...

Ngày tải lên: 09/08/2014, 10:23

... daily intraperitoneal injection of the HO-1 inhibitor zinc-protoporphyrin (ZnPP, Porphyrin Products, Logan, UT, USA) at a concentration of 50 μmol/kg/day, starting two days before and continuing ... et al.: Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium Journal of Biomedic...

Ngày tải lên: 10/08/2014, 05:21

... with a table that contains each ~-expression and the ima6e of its denotation in the current stage of the dynamic model When the domain of the ~-expression expands, the correct denotational relationship ... have the model contain the inconsistent information that "John and Mary talk" is true and that "Mary and John talk" is false If two non-equivalent ~-expressions were identif...

Ngày tải lên: 21/02/2014, 20:20

... kraft pulp mill based on data from a model mill depicting a typical Scandinavian pulp mill As an addition, Papers IV, VI and VIII are based on data from existing European pulp and paper mills and ... pulp and paper industry Model Paper III Research theme The papers are based on data for a typical Scandinavian kraft pulp mill of today Methodology and mod...

Ngày tải lên: 22/02/2014, 09:20

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein na...

Ngày tải lên: 23/03/2014, 03:20

... TGF-β1 in the urine of male rats after CYP were also significantly higher than the levels of active and total TGF-β1 in the urine of female rats, both at baseline and after CYP (ANOVA, Tukey post ... control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine of CYP-treated female rats remained higher as compared to both CY...

Ngày tải lên: 11/08/2014, 08:22

... 10.1186/ar3062 Cite this article as: Kerachian et al., New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model Arthritis ... vessels of the femoral head In fact, the vascular hypothesis (regional endothelial bed dysfunction) appears to be relevant in the pathogenesis o...

Ngày tải lên: 12/08/2014, 14:22

... 5'-GAACAACATGCATTCCGAGAAG-3' Forward: 5'-GCGCAGCGCGTTGAA-3' Probe: 5'-AACGAACAGTCATCACCACATCTCATCCAG-3' Reverse: 5'-GGATGGAGCTCGTCCAAGTG-3' Forward: 5'-GCCATCCTGACTATTTCACTGAAGA-3' Probe: 5'-AAGCCTACTTTTTCTCAAGGGCAGTCACCG-3' ... was therefore used as an internal control Statistical analysis All statistical analyses were done using StatView software (SAS Institute Inc., Cary, NC, USA) Data wer...

Ngày tải lên: 13/08/2014, 19:20

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25