... N- and C-terminal parts of the ligand are cross-linked to domains I and III, respectively, of the receptor [19,22] The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ... cognate ligand, EGF, we verified the assays using the chimeras, because the contributions of the ErbB-1 ectodomains to the EGF binding had already been established by the study with the chicken and human ... contributions of the domains of ErbB-1 to the EGF signaling and those of ErbB-4 to the NRG signaling Analyses using chimeric receptors are very useful to elucidate the relative contributions among the...