Serum amyloid a (SAA) and cholesterol efflux a mechanistic study

... cardiovascular disease and diabetes 41 1.4.6 SAA and cardiovascular disease The characterization of SAA as both an inflammatory protein and an apolipoprotein generate increased interest in CAD ... HepG2 cells was mediated by ABCA1 and ABCG1 107 12 SAA enhances PPAR activation and SAA-induced PPAR target genes expressions are inhibited by PPAR antagonist 13 SAA-induced PPAR activity...

Ngày tải lên: 10/09/2015, 15:51

... 1.9 11.3 ± 2. 1 12. 1 ± 2. 0 11.9 ± 1.4 2. 2 – 3.1 2. 2 – 3.1 2. 2 – 2. 8 2. 5 – 3.4 2. 2 – 3.1 2. 2 – 2. 8 2. 2 – 3.1 2. 2 – 3.7 2. 5 – 3.1 1–1 0–1 0–1 0–1 Overall Mean 15 15 10 2. 2 – 3.7 2 4 37.5 ± 4.0 11.4 ... PCV2a and PCV2b in the field Virus Res 20 07, 1 32: 201 -20 7 Page of 11 (page number not for citation purposes) Acta Veterinaria Scandinavica 20 09, 51:13 10...

Ngày tải lên: 12/08/2014, 18:22

... the SAA levels in the ORP maxima plasma samples as an accurate measurement of SAA maxima levels Additionally, the correlation between the ORP maxima day and SAA maxima day further validates the ... ORP and SAA maxima around day suggesting that an additional trauma on this day could result in maximal oxidative damage to an already compromised patient In healthy humans, antioxidants...

Ngày tải lên: 13/08/2014, 23:21

... extended conformation Remarkably, ibuprofen, a nonsteroidal anti-inflammatory agent [12], and warfarin, an anticoagulant drug [12], are considered as stereotypical ligands for Sudlow’s site II and Sudlow’s ... HSA inhibits ibuprofen and warfarin association to the warfarin primary cleft (i.e Sudlow’s site I), corresponding to the ibuprofen secondary site [1,3,11] Then, i...

Ngày tải lên: 31/03/2014, 23:20

... not a major acute phase protein and has not been regarded as a biomarker of CAD 1.4 Endothelial proinflammation 1.4.1 Endothelial proinflammation in atherosclerosis Ross proposed in 1999 that atherosclerosis ... acute inflammation, its an-inflammatory function could be reduced 15 1.2.2 A biomarker of atherosclerosis The characterization of SAA as both an inflammato...

Ngày tải lên: 14/09/2015, 13:15

... minimization of tissue damage and promotion of healing (Baranova et al., 2010; Sandri et al., 2008) In the event of a tissue injury, the acute phase response initiates the activation of a cascade, ... indication of the involvement of macrophages in plaque rupture (Boyle, 2005) 1.3 Serum Amyloid A (SAA) SAA is a 12.5kDa acute phase reactant which plays a...

Ngày tải lên: 12/10/2015, 17:36

... particular surface and the chemistry of the corrosion process A single surface will display distinct anodic and cathodic Tafel slopes ( a and βc) A large value of β means that a surface polarizes ... satisfactory inhibition effect on lead leaching from brass pipes It works as an “aging accelerator”, which means that the leaching of lead dramatically decreased and the duration...

Ngày tải lên: 22/10/2015, 22:43

... cholesterol in macrophages that transform into foam cells This effect is restored by the addition of prostaglandins AA, arachidonic acid; ABCA1, ATP-binding cassette transporter A1 ; COX, cyclooxygenase; ... Statistical analysis of experimental data Statistical analysis was performed using SigmaStat version 2.03 (SPSS Inc., Chicago, IL, USA) Data was analyzed using the Kruskal-W...

Ngày tải lên: 09/08/2014, 10:20

... A, Nagasawa T & Era S (2004) Alteration of redox state of human serum albumin before and after hemodialysis Blood Purif 22, 525–529 10 Tomida M, Ishimaru J, Hayashi T, Nakamura K, Murayama K ... suggestions We are grateful to Dr Masaichi-Chang-il Lee, Clinical Care Medicine Division of Pharmacology, Kanagawa Dental College, for valuable advice on ESR analysis We also thank Dr I...

Ngày tải lên: 16/03/2014, 13:20

... increased data throughput [18-20] Two commercially available approaches are PeakForce QNM and Harmonic force microscopy or HarmoniX (Veeco, Santa Barbara, CA, USA) PeakForce QNM is based on the force- volume ... nN) and C and D in ambient conditions (setpoint is 16 nN) The fibrils have in these images an average modulus of elasticity of GPa and mica between and GPa Imag...

Ngày tải lên: 21/06/2014, 04:20

... discussion 315-6 Shimada H, Hasegawa N, Koh H, Tasaka S, Shimizu M, Yamada W, Nishimura T, Amakawa K, Kohno M, Sawafuji M, Nakamura K, Fujishima S, Yamaguchi K, Ishizaka A: Effects of initial ... digitally scanned and integrated signal intensity of bands was calculated by image analysis (NIH Image J) Approximately 50 mg of liver was homogenized in mL of Trizol reagent, and tota...

Ngày tải lên: 11/08/2014, 08:21

... died waiting for LT In following analysis we considered the fatal patients and those who were transplanted as one category because the pathological examination showed that the livers of all transplant ... measured using the 7500 Clinical Analyzer (Hitachi High-Technologies Corporation, Tokyo, Japan) LDH was assayed using an enzymatic rate method with lactate as the s...

Ngày tải lên: 13/08/2014, 13:20

... liver and renal failure in the ROC analysis It is tempting to speculate that increased collagen propeptide levels found are at least partly due to increased synthesis and are likely to be a summation ... associated with enhanced collagen synthesis and it has been shown to augment collagen prolyl 4-hydroxylase activity in vitro [37] Tissue hypoxia and activation...

Ngày tải lên: 13/08/2014, 16:20

... article as: Yousef et al.: The value of correlation of serum 20S proteasome concentration and percentage of lymphocytic apoptosis in critically ill patients: a prospective observational study ... aspartate aminotransferase, alanine aminotransferase, albumin and C-reactive protein, and arterial blood gas analysis were recorded Routine cultures of u...

Ngày tải lên: 14/08/2014, 07:21

... In the Laboratory and (iii) the advantages and disadvantages of vegetable and animal food sources, considering cholesterol- related health problems This work can be expanded in further lab sessions: ... can be done in a quantitative way, using a spectrophotometer; students can design a cholesterol standard curve and measure the absorbance of the blue–green complex at 550 nm...

Ngày tải lên: 02/08/2015, 14:08