Alpha fluorinated aromatic ketone as nucleophile in asymmetric organocatalytic c n and c c bonds formation reactions 4a

... deprotonation/deuteriation process 2. 2 Enantioselective H/D exchange of  -fluorinated aromatic ketones 2. 2.1 Synthesis of  -fluorinated aromatic cyclic ketones and chiral bicyclic guanidine catalyst ... much (entries 12- 13) Table 2. 1 Optimization of the asymmetric H/D exchange reaction of  -fluorinated ketone 82a in different conditions (Scheme 2. 6) incorporation en...

Ngày tải lên: 10/09/2015, 15:51

... 3.7 Asymmetric amination reation of  -fluorinated aromatic cyclic ketone Scheme 3.8 Other  -fluorinated compounds tested in asymmetric amination a Conversion of corresponding products determined ... cyclic ketone nucleophiles in asymmetric amination reaction catalyzed by chiral bicyclic guanidine Under the optimal reaction conditions, the chiral -hydrozino- -fluorinated...

Ngày tải lên: 10/09/2015, 15:51

...  -fluorinated aromatic ketones in the asymmetric Mannich and Michael reactions 4.2 Asymmetric Mannich reaction of  -fluorinated aromatic ketones 4.2.1 Synthesis of imines and pentanidines; Pentanidines ... Enatioselective C- C bond formation 4.1 Introduction Asymmetric C- C bond formation reactions are important reactions in organic synthesis Among the variou...

Ngày tải lên: 10/09/2015, 15:51

... 121 Experimental Colorless oil LRMS (ESI) m/z 55 1.3 (M+Na+); 5. 5 Protocol for bicyclic guanidine catalyzed asymmetric C- C bond formation reactions and characterization of products Procedures for ... 254 nm; retention time: major isomer: 124.3 min; minor isomer: 132.8 5. 4 Protocol for bicyclic guanidine catalyzed asymmetric C- N bond formation reaction and characteriza...

Ngày tải lên: 10/09/2015, 15:51

... asymmetric conjugated addition reactions Most aliphatic ketone and acetophenone nucleophiles used in organocatalytic asymmetric transformations rely on the formation of highly reactive enamine intermediates.1 ... basic phase-transfer conditions We will describe the asymmetric H/D exchange reaction, C- N and C- C bonds formation reactions catalyzed by our guanidin...

Ngày tải lên: 10/09/2015, 15:51

... Alismatis and Radix Angelica Sinensis inhibited the formation of TG Discussion The potential of some Chinese medicinal herbs against obesity in terms of stimulating ApoA-IV promoter activity in gut ... obtainable only in the presence of other appropriate Figure Transcriptional activation of ApoA-IV by Chinese medicinal herbs Transcriptional activation of ApoA-IV...

Ngày tải lên: 13/08/2014, 15:21

... protein tyrosine phosphatases (PTPs) are considered as excellent examples, as illustrated in Figure The consequences of oxygen activation in human bodies are indeed increasingly observed but only ... nitrogen species, such as nitric oxide and peroxynitrite, are biologically relevant O2 derivatives increasingly being recognized as important in vascular biology potential7 Starting...

Ngày tải lên: 26/10/2012, 09:48

... for the Problems of Mother Tongue Interference in Learning English Sounds and Stress In this chapter, tips and exercises that help learners of English avoid the problems of Mother Tongue Interference ... Discussions After investigating the pupils by using the survey questionnaire, the following findings will show the mother tongue interferenc...

Ngày tải lên: 18/12/2013, 21:45

... pathway scoring for calculating semantic similarity in conceptnet In Proceedings of the Ninth International Conference on Computational Semantics, pages 385– 389 Association for Computational Linguistics ... visualizing opinions and sentiments in a multi-dimensional vector space Knowledge-Based and Intelligent Information and Engineering Systems, pages 385–393 E Cambria, R Speer, C Ha...

Ngày tải lên: 19/02/2014, 19:20

... et al Staphylococcal nuclease refolding investigated Two point-mutated proteins, with a single base substitution of alanine for tryptophan (W14 0A) and alanine for lysine (K13 3A) , and two truncated ... both the wild-type protein and mutants E142O and K13 3A Thermal analysis of protein unfolding The DSC curves of the wild-type protein and the mutants K13 3A,...

Ngày tải lên: 20/02/2014, 01:20

... by studying sin and thinking about sin; and no one ever got rich by studying poverty and thinking about poverty Medicine as a science of disease has increased disease; religion as a science of ... begin to have capital The getting of capital is a part of the process of getting rich; and it is a part of the result which invariably follows the doing of t...

Ngày tải lên: 06/03/2014, 09:21

... Liang 1986 Basic Engineering for Chinese Processing – Contemporary Chinese Words Frequency Count, Journal of Chinese Information Processing, 1(1):17-25 Robert W.P Luk, K.L Kwok 1997 Comparing representations ... space during the increase of dimensionality With these factors, the actual curves would not keep increasing as they in Figure b1,2 ⊂ w in which b1 and b2 stand for...

Ngày tải lên: 08/03/2014, 02:21

... species 2.0 Inclusion level (percent) Results of investigations on the use of algae as additives in fish feed Table 1.3 12 Use of algae and aquatic macrophytes as feed in small-scale aquaculture ... doubles its biomass in 3-10 days, depending 18 Use of algae and aquatic macrophytes as feed in small-scale aquaculture – A review on con...

Ngày tải lên: 14/03/2014, 11:21

... determination model learns the non-anaphoric class directly from non-anaphoric training instances whereas the single-step model cannot not use non-anaphoric cases in training (φi -ga) suishinsuru ... of parameter θintra is not difficult We next evaluated the effects of introducing the proposed model on overall zero-anaphora resolution including inter-sentential cases As a baseline model,...

Ngày tải lên: 17/03/2014, 04:20