... Approaches for understanding pathogenic roles Z Yue function [5] LRRK2 also contains armadillo-like repeats, LRR, kinase and WD40 domains [6] In vitro biochemical analysis demonstrates that LRRK2 ... to investigate LRRK2 structure ⁄ function-related proteins (e.g ROCO family proteins) in various model systems, including lower eukaryotes and invertebrates, in order to obtain clues for building ... illustration of domain structures and alignment for LRRK2 and LRRK2 structure-related proteins ANK, N-terminal ankyrin repeat domain; DEP, Dishevelled, EGL-10, pleckstrin domain; GEF, guanine-exchange...