Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN -REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... signaling 21 1.3.4 Regulation of estrogen receptors 23 1. 3.5 Estrogen and estrogen receptors in human breast cancer 27 v 1. 4 THE SODIUM HYDROGEN EXC...

Ngày tải lên: 10/09/2015, 15:49

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that p...

Ngày tải lên: 04/10/2015, 17:05

... replication by drugs that block eIF5A modification Inhibition of HIV replication by drugs that block eIF5A modification A Hypusination of eIF5A (gray) occurs in two steps: the transfer, catalyzed by DHS, ... DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, cat...

Ngày tải lên: 12/08/2014, 23:22

... Regulation of activity and expression of NHE 1 54  1. 4.4 A  1. 4.4 B  1. 5  Regulation of NHE -1 activity 54  Transcriptional regulation of NHE -1 expression .58  AIM OF STUDY 61 ... response repression of NHE -1 expression .11 1  Figure 13 : Thiol oxidizing agent diamide mimicked the effect of H2O2 in the downregulation of NHE -1 gene expression 11 3  Figu...

Ngày tải lên: 14/09/2015, 08:50

... Sam68ΔC Understanding regulation of Understanding regulation of HIV-1 gene expression by Sam68ΔC (A) Following transcription, HIV-1 RNA undergoes alternative splicing to generate over 40 mRNAs that ... next page) Page of (page number not for citation purposes) Retrovirology 2009, 6:22 http://www .retrovirology. com/content/6/1/22 Figure (see previous page) HIV-1 gene ex...

Ngày tải lên: 12/08/2014, 23:20

... investigated dimerization and the role of oxidation in dimerization of a panel of four different RPTPs We compared four RPTPs from different subtypes, i.e RPTPa, RPTPl, CD45 and LAR We found that the ... native RPTPa, or to the presence of low amounts of monomers Nevertheless, there was a clear difference in accessibility between oxidized and reduced LAR, R...

Ngày tải lên: 18/02/2014, 17:20

... Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo Clinical Sarcoma Research 2011 1:5 Submit your ... investigated the effect of ESR -signaling modulation on the proliferation of chondrosarcoma cells in vitro by measuring the effect of...

Ngày tải lên: 13/08/2014, 15:21

... Imhof and McDonnell 1996) Transcriptional controls from histones Another significant transcriptional control is the discovery of histones and their functions to control the accessibility of chromatin ... as one of the factors for predicting and diagnosing breast cancer (Ali and Coombes 2000) Estrogen receptor belongs to the family of steroid receptor and is activat...

Ngày tải lên: 14/09/2015, 14:05

... hsa-miR-769-5p RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors Figure RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors The figure ... significantly higher inhibitory activity in ER- cancer, strongly indicating that the differential regulatory effects of miRNAs can not be explained by miRNA ex...

Ngày tải lên: 09/08/2014, 20:20

... activity and expression profiles of target genes A number of genes, including those for trefoil factor 1/ pS2, cathepsin D, cyclin D1, c-Myc and progesterone receptor, are positively regulated by ... factor binding elements occur very frequently in the genome, finding an ERE, AP-1 or Sp1 site only in ER-responsive genes is highly unlikely Instead, we asked whether the pr...

Ngày tải lên: 14/08/2014, 14:21

... relevance) THE EUROPEAN PARLIAMENT AND THE COUNCIL OF THE EUROPEAN UNION, Having regard to the Treaty on the Functioning of the European Union, and in particular Article 114 thereof, Having regard to the ... either by the European Parliament or the Council within a period of two months of notification of that act to the European Parliament...

Ngày tải lên: 19/02/2014, 14:20

... lacked the last 42 amino acids Figure 2A and Table show that the ATPase activity of NBD2-DC was greater than that of SUR2B but similar to that of NBD2A, favoring the idea that the last 42 amino acids ... than those for the NBDs of SUR2A [22] SUR2A and SUR2B differ only in their last 42 amino acids, which not form part of the catalytic site Thus,...

Ngày tải lên: 06/03/2014, 11:20

... and urban transport EN EN 2011/0274 (COD) Proposal for a REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on the Cohesion Fund and repealing Council Regulation (EC) No 1084/2006 THE EUROPEAN ... general provisions on the European Regional Development Fund, the European Social Fund and the Cohesion Fund and repeali...

Ngày tải lên: 07/03/2014, 16:20

... role of acylCoA synthetases and thioesterases in the regulation of steroidogenesis by using triacsin C and NDGA on ACTHstimulated steroid synthesis in Y1 cells For this purpose, ACTH-stimulated Y1 ... Neuman, I., Finkielstein, C.F & Podesta, E.J (1997) Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced...

Ngày tải lên: 08/03/2014, 09:20

... characteristics of the genetically modified food to those of comparable food; • A discussion of “available data” on the allergenic and toxic potential of the modified food; • A description of any applications ... and its products could be the subject of regulatory review This report is intended to provide a general descriptive guide to the current set of...

Ngày tải lên: 13/03/2014, 21:59