Developing chemical proteomic tools connecting proteins and small molecules

... of chemical proteomics tools that span various analytical modes, effectively expanding the chemical proteomics labelling’s application on both specificity and scope These include chemical (small ... 1.4.2 Affinity/Activity Based Chemical Proteomic Tools A popular approach of chemical proteomics relies on design and synthesis of chemical probes that can react with prote...

Ngày tải lên: 10/09/2015, 15:49

... 2010 FEBS 4349 Functional classification of scaffold proteins L Buday and P Tompa Table Scaffold proteins and their kin Representatives of the four categories of scaffold proteins and their relatives ... L Buday and P Tompa Functional classification of scaffold proteins A B A Adaptor B B A C Scaffold/ anchor C Docking P P P P Fig Mechanisms of scaffol...

Ngày tải lên: 06/03/2014, 22:21

... In these authors’ opinions, such studies obviously represent the next logical step in the unfolding story of the modulation of the oligomeric structures of HIV-1 viral enzymes by synthetic peptides ... 75% of the total Gibbs energy [15] The importance of this four-stranded b sheet is further emphasized by the fact that all PR dimerization inhibitors d...

Ngày tải lên: 08/03/2014, 09:20

... 3021 23 Chapter Graphene Oxide Induced Aggregation of Thiophene-Acrylonitrile-Carbazole Oligomer and Their Nonlinear Optical Limiting Properties 3.1 Introduction Nonlinear Optical limiting (NLO) ... rational modification of both the electronic structure and conductivity of graphene sheets accompanied by additional thermal reaction of nano -graphene units lead...

Ngày tải lên: 30/09/2015, 14:23

... transduction pathways in eukaryotes 1.4 Small Molecule Chemical Biology Tools for Studying Cellular Phosphorylation Events in vivo 1.4.1 Small- Molecule Mimetics of Phosphorylated Amino Acids The elucidation ... Molecule Chemical Biology Tools for Studying Cellular Phosphorylation Events In vivo 1.4.1 Small- Molecule Mimetics of Phosphoryl...

Ngày tải lên: 04/10/2015, 15:45

... Dementia, gliosis and expression of the small heat 2625 Small heat shock proteins and disease 120 121 122 123 124 125 126 127 128 shock proteins Hsp27 and [alpha]B-crystallin in Parkinson’s disease Neuroreport ... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and smal...

Ngày tải lên: 19/02/2014, 18:20

... describe the design and synthesis of OrlistatTM -like natural product -based probes (Chapter 2, & 4), K11777 -like drug candidate -based probes (Chapter 5) and azanitrile-containing small molecules (Chapter ... 1.2 Activity- Based Protein Profiling (ABPP) 1.2.1 Introduction 1.2.2 Activity- Based Probe Design 1.2.3 Bioorthogonal Chemistry in ABPP 10 1.2.4 Application...

Ngày tải lên: 09/09/2015, 18:54

... modifications of a protein may also involve the attachment of other proteins or peptides, such as ubiquitin and the small ubiquitin- like modifier (SUMO) Subsets of a pool of proteins may be modified ... according to the cellular conditions and microenvironment as part of the cellular response and regulatory processes 1.1.1 Small Ubiquitin- like Modifier...

Ngày tải lên: 11/09/2015, 10:18

... 3D proteomics: Analysis of proteins and protein complexes by chemical cross- linking and mass spectrometry Zhuo A Chen Thesis for the Degree of Doctor of Philosophy The University of Edinburgh August ... proteomics analysis of the Pol II complex 96 4.3.1 Cross- linking/ MS analysis of the Pol II complex 96 4.3.2 Cross- linking and protein- protei...

Ngày tải lên: 30/09/2015, 05:51

... Developing Intuition Series The Developing Intuition Series By Sandy Breckenridge and Kirk VandenBerghe Inttroducttiion: Channelliing In roduc on: Channe ng Warm greetings to you My name is Kirk ... to you My name is Kirk VandenBerghe, and I’ll be your guide as I interview Alana, who is conveyed by my partner and soul mate, Sandy Breckenridge We are presen...

Ngày tải lên: 15/12/2013, 05:15

... traversing the enterprise network Business Ready Branch Solutions for Enterprise and Small Offices—Reference Design Guide OL-7470-01 2-11 Chapter Planning and Designing the Business Ready Branch Solution ... percent for high quality voice Business Ready Branch Solutions for Enterprise and Small Offices—Reference Design Guide 2-12 OL-7470...

Ngày tải lên: 21/12/2013, 06:16

... Survey of interval methods for ODE’s, http://www.eng.mu.edu/corlissg/Pubs/03Lyngby/Slides/ [2] N S Nedialkov, Interval tools for ODEs and DAEs, http://www.cas.mcmaster.ca/∼ nedialk/PAPERS/intvtools/intvtools.pdf ... methods for classes of problems may be a feasible approach • An efficient method for stiff problems is needed • An interval version“ of DETEST, a test set for...

Ngày tải lên: 12/01/2014, 21:46

... overexpressing a- synuclein A proteomic analysis is expected to identify cellular alterations that are associated with dopamine treatment and modulated by a- synuclein overexpression, without any a priori ... eukaryotic initiation factor 5A (eIF 5A) , parathymosin, L7 ⁄ L12, annexin A2 , annexin A5 , aldolase A, fascin and peroxyredoxin 1] displayed quantitative diff...

Ngày tải lên: 15/02/2014, 01:20

... passed on to small businesses in the form of lower prices Despite these positive aspects of the transformation of banking, one important concern remains about the impact on local economies—with the ... Source: Summary of Deposits, National Information Center Database II IMPACT OF THE CHANGES ON CONSUMERS Consumers have traditionally relied on nearby ba...

Ngày tải lên: 16/02/2014, 11:20