Posttranscriptional regulation of erythropoiesis by RNA binding proteins and microRNAs

... Primary miRNAs are transcribed and processed by Drosha and DGCR8 to form pre-miRNAs pre-miRNAs are transported out of nucleus by RAN-GTP and Exportin-5 and further processed by Dicer and loaded ... are shown32 5.6 microRNAs in erythropoiesis microRNAs are a class of small non-coding RNAs involved in the regulation of many biological processes through the downregu...

Ngày tải lên: 10/09/2015, 09:23

... is in accordance with the highly increased cytokine and chemokine secretion induced by poly(I:C) and emphasizes the strong proinflammatory impact of the TLR3 ligand poly(I:C) for SAEC Regulation ... expression of other TLRs and proteins involved in TLR signaling in SAEC In addition, we demonstrate that the expression of TLRs and their signaling p...

Ngày tải lên: 11/08/2014, 08:21

... phosphorylation by Prk1p and possibly Ark1p kinase These kinases constitute a unique family of actin regulating kinase whose substrates include many components of actin machinery as well as endocytic and ... depolymerization Actin bundling proteins such as Sac6p and Abp140p can be found coating the actin cables, and bind actin filaments together to form a cable...

Ngày tải lên: 14/09/2015, 08:50

... discrimination We anticipate that the performance of the potential will only increase with the size of the structural database and as terms are added to the model to account for protein and RNA intra-molecular ... structural data available for training Nevertheless, the distancedependent potential function already performs on par with the amber and rosetta force...

Ngày tải lên: 18/02/2014, 16:20

... shown) Inhibition of pneumococcal murein hydrolases by bicyclic amines As shown above, tropic esters of bicyclic amines were selected and characterized by biophysical methods as strong ligands ... that the bicyclic amines are also able to bind to the active site of Pce Effect of choline analogs on cell growth and viability Fig Effect of choline and an...

Ngày tải lên: 19/02/2014, 05:20

... anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5827 Fig Helical wheel representations of protein segments The C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b, and the primary sequence of ... 0 .65 0.23 Ó FEBS 2002 Membrane anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5823 The peptides P4 and P5 (Table 1) were supplied...

Ngày tải lên: 31/03/2014, 08:20

... Defining potentially conserved RNA regulons of homologous zinc-finger RNA- binding proteins Genome Biology 2011 12:R3 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... intron of ZNF9 cause myotonic dystrophy type (DM2) DM2 is characterized by heterogeneous, multi-systemic symptoms, including myotonia [29] The disease is thought to be...

Ngày tải lên: 09/08/2014, 22:23

... analysis of the amino acids located in the amino-terminal extensions that lie outside of the PUM-HD in AtPum proteins A comparison of the percentage of amino acid identity and similarity for the amino ... resulting in an amino acid triplet that matches that of Puf repeats and in the conserved proteins Interestingly, this CRQ triplet is also found in r...

Ngày tải lên: 12/08/2014, 03:21

... hours of culture [52], the majority of their genomic RNAs may have been matured by slow-acting dimerization site(s), which may explain why most of their SL1 mutations were phenotypically silent ... entrapment may have twin roles in the regulation of lentiviral leader RNA dimerization since promoting SL1 presentation by increasing its folding stability (Table 3) may favor...

Ngày tải lên: 13/08/2014, 05:21

... box proteins may have roles in maintaining HIV latency If this reasoning is correct, then the selective targeting of such DEAD box factors might offer another means of ending HIV latency and ... activity were also up regulated during this period, including the methylated mRNA cap binding proteins EIF4G1 [27] and NCBP1 (CBP80) [28], which function in translation initiat...

Ngày tải lên: 13/08/2014, 13:20

... comprehensive proteomics analysis of 14-3-3-binding proteins under physiological conditions as compared with apoptosis stimulation, with the aim of increasing our knowledge of the role of 14-3-3 proteins ... changes in 14-3-3-binding patterns in HeLa cells during C2-ceramideinduced apoptosis With the aim of further analyzing the role of 14-3-3 proteins in apopto...

Ngày tải lên: 06/03/2014, 22:21

... myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells Sixty percent of polycytemia vera patients have diminished expression of SHP-1 in CFU-E populations ... Ó FEBS 2002 Transcriptional regulation of erythropoiesis (Eur J Biochem 269) 3615 of these key transcriptional regulators of the erythropoietic process and notes at...

Ngày tải lên: 08/03/2014, 22:20

... 6075 p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage- induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... (2009) 607 4–6 083 ª 2009 The Authors Journal compilation ª 2009 FEBS N Bitomsky & T G Hofmann p53, p73 and HIPK2 in apoptosis Fig Regulation of...

Ngày tải lên: 16/03/2014, 00:20

... levels is mainly achieved by modulation of secretases, namely by the induction of a-secretase activity, by inhibition of b -secretases and ⁄ or c -secretases, or by a combination of both This study provided ... Regulation of secretases by retinoic acid A Koryakina et al use of several potential PKC activators, such as phorbol esters Therefore, an assessment of...

Ngày tải lên: 16/03/2014, 01:20

... of DNp63a by TNF-a was attenuated by inhibition of NF-jB, suggesting that activation of NF-jB may be involved in the regulation of the degradation of DNp63a Interestingly, knockdown of DNp63a expression ... function of DNp63a for epidermal stem cell proliferation, we were interested to know whether factors involved in maintaining epidermal homeostasis affect...

Ngày tải lên: 16/03/2014, 06:20