... tissue, (insets) CsA-treated Fabry (A, B) Heart – endothelial staining in Fabry mouse; (C, D) lung – epithelial cell staining increased in Fabry mouse; (E, F) brain microvascular endothelial staining ... Chiba Y, Sakuraba H, Kotani M, Kase R, Kobayashi K, Takeuchi M, Ogasawara S, Maruyama Y, Nakajima T, Takaoka Y et al (2002) Production in yeast of alpha-galactosidase A, a lysosomal enzyme applicable ... inhibition of MDR1 as an approach to the treatment of Fabry disease Although the efficacy may not, as yet, be as dramatic as ERT, inhibition of MDR1 may prove most beneficial as an adjunct, rather than alternative...