Composite controlled release system of nitric oxide for cardiovascular tissue engineering application
Composite controlled release system of nitric oxide for cardiovascular tissue engineering application
... COMPOSITE CONTROLLED RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE ... illustration of the proposed composite controlled release system of NO is depicted in Figure 1-1 There are three main parts in the composite system: supportive film, NO donor, and host of NO donor ... components Therefore, choices of appropriate materials and techniques with fewer limitations are crucial for the development of composite vascular grafts 2.4 Nitric Oxide Nitric oxide (NO) is a...
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Nanofibrous surface modification of ultra thin PCL membrane for cardiovascular tissue engineering application
... tissue engineering application This thesis reports on a novel hybrid nanofibrous PCL membrane scaffold for cardiovascular tissue engineering application, achieved by surface modification of the PCL ... methods in nanofibrous surface modification of PCL membrane are presented in details Ultra- thin PCL membrane was prepared via 2-rollheated-mill, melt press and biaxial stretching method The PCL membrane ... presents the results of nanofibrous surface modification of PCL membrane in terms of surface characterization and cell behavior studies The results showed that uniform nanofibrous topology were...
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Design and development of a bioreactor for ligament tissue engineering
... (lateral collateral ligament and medial collateral ligament) , and two interior ligaments (anterior cruciate ligament (ACL) and posterior cruciate ligament) , which help control stabilisation and ... Rotating Wall Bioreactor 28 2.2.2.3 The Flow Perfusion Bioreactor 29 CHAPTER 3: DESIGN AND FABRICATION OF BIAXIAL MECHANICAL STIMULATION AND PERFUSION BIOREACTOR 32 3.1 DESIGN CRITERIA 32 3.2 MATERIAL ... field of tissue engineering has shown to be a promising alternative in using cell transplantation as a strategy to achieve tissue repair and regeneration for a variety of therapeutic needs One approach...
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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
... tighter binding of cadmium than zinc in metallothioneins and the preference of zinc in the more flexible b-domain In addition to the already described differences in flexibility of the b-domain in MT ... reported increased metal release in the presence of oxidized glutathione (GSSG) and even slightly tighter metal binding under the in uence of reduced glutathione (GSH) [37] We investigated in vitro the ... the a-domain Recently, Maret and coworkers found a large difference in the amount of metal released by NO in the two domains of MT3 [49] Zinc from the b-domain was set free much easier than from...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot
... morphological criteria The murine macrophage cell line RAW264.7, originally from the American Type Culture Collection (Manassas, VA, USA) and maintained in our laboratory, was also used For cell ... antibody pairs A 96-well EIA/RIA plate (Corning Inc.), coated with a coating antibody and masked with skim milk, was incubated with test samples and standard solutions A biotin-labeled detecting antibody ... production in murine macrophage cell line culture, but a minor pathway in peritoneal cell culture The indirect pathway, through IFN-c, was indicated to play the major role in the peritoneal cell...
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Tài liệu Báo cáo " Development of system of HydrodynamicEnvironmental models for coastal area (Case study in Quang Ninh - Hai Phong region) " doc
... d) after 12 days in Ha Long Bay area: a, b - SE wind, c, d - NE wind Development of system of hydrodynamic-environmental models for coastal area 65 The field sampling results in September 2005 ... 1/2003, pp 10 8-1 13 (in Vietnamese) [7] Dinh Van Uu et al (2005), Application of the 3D water circulation model for studying SPM transport processes in Quang Ninh coastal area Proceedings of National ... Distribution of particulate concentration in water (depth 0.5m) after (a) and 24 (b) hours in the SE direction wind Development of system of hydrodynamic-environmental models for coastal area 67 In the...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inhibited by the coexistence of a-T, TA and TN ... the VSMC, but TS was not hydrolyzed to a-T and succinic acid [32] Accordingly, the enhancement of LPS/IFN -induced NO production is attained by TS itself rather than a derivative TS enhanced LPS-dependent...
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Báo cáo khoa học: Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs potx
... isoforms of NOS with CaM-TnC chimeras demonstrated that the roles of the four EF hands in the binding and activation of the cNOS and iNOS enzymes are distinct [13] Replacement of any CaM EF hand ... enzymes during binding and activation [4,5] The present investigation, designed to further assess the role of the two CaM EF hand pairs in the binding and activation of nitric oxide synthase (NOS; EC ... of the target peptide with EF hand in closest contact with the reductase domains The central helix is composed of the C-terminal and N-terminal helices of EF hand units and 3, respectively, and...
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Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... Ca2+ Degradation of NOS isozymes by calpain binding capacity of calpain The physiological relevance of this novel property of HSP90 is also discussed Results Degradation of NOS isozymes in Ca2+ ... intracellular localization of the synthase Degradation of NOS isozymes by calpain The physiological relevance of these findings becomes particularly evident on the basis of the results observed in ... Involvement of the proteasome in activation of endothelial nitric oxide synthase Life Sci 73, 2225–2236 Musial A & Eissa T (2001) Inducible nitric- oxide synthase is regulated by the proteasome degradation...
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Báo cáo khoa học: Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase pptx
... hydrophobic anchors Given the length of the first helix of cupiennin 1a, and the number of hydrophobic anchors available, it seems likely that the cupiennin 1a ⁄ Ca2+-CaM complex is analogous to the structure ... that cupiennin 1a also complexes with Ca2+-CaM, and is one of the more active of the known peptide inhibitors of nNOS Cupiennin 1a from Cupiennius salei Results Cupiennin 1a was tested for the ... this peptide showed some structural features in common with certain amphibian peptides that inhibit the formation of NO by neuronal nitric oxide synthase (nNOS) [10] These particular amphibian peptides...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... In vivo degradation of NOS and HSP90 by calpain M Averna et al Table Levels of native and 15 kDa calpastatin species in brain and aorta of NMS and HMS rats treated with HSD for weeks The data ... compilation ª 2008 FEBS M Averna et al In vivo degradation of NOS and HSP90 by calpain higher than in aorta, resulting in a much higher HSP90 to NOS ratio in brain (Fig 1C) A Calpain activation in ... inactivated As both the inactivation and fragmentation of calpastatin are known to be produced by active calpain [32], these observations further indicate that calpain is activated in both tissues, although...
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báo cáo hóa học: " Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells" pptx
... in the human brain after fatal head injury J Neurotrauma 2002, 19:279-84 Macdonald NJ, Taglialatela G: Tumor necrosis factor alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma ... Cuzzocrea S: Inhibition of the nuclear factor- kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats J Neurosurg ... example, inflammatory involvement in AD pathogenesis has been proposed partly based on observations of increased levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and...
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Báo cáo hóa học: " Research Article Algorithms of Common Solutions to Generalized Mixed Equilibrium Problems and a System of Quasivariational Inclusions for Two Difference Nonlinear Operators in Banach Spaces" pdf
... Motivated by the work of Combettes and Hirstoaga 34 in a Hilbert space and Takahashi and Zembayashi 33 in a Banach space, Zhang 35 and also authors of 36 obtained the following lemma Lemma 2.2 see 35 ... Saewan and P Kumam, A hybrid iterative scheme for a maximal monotone operator and two countable families of relatively quasi-nonexpansive mappings for generalized mixed equilibrium and variational ... 23 31 X Qin, S S Chang, Y J Cho, and S M Kang, “Approximation of solutions to a system of variational inclusions in Banach spaces,” Journal of Inequalities and Applications, vol 2010, Article...
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Báo cáo khoa học: "Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis" pdf
... the Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 13 appropriate biotinylated second antibody and the avidinbiotin peroxidase ... der Valk, P Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis J Neuropathol Exp Neurol ... The increased expression of NT during the peak stage of EAE suggests that peroxynitrite or NO is generated in the autoimmune spinal cord lesions Fig Immunostaining of three isoforms of NOS in...
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Báo cáo khoa học: "Expression of nitric oxide synthase isoforms in the porcine ovary during follicular development" ppsx
... localization of neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms of nitric oxide synthase (NOS) in the ovaries of pigs The intensity of staining is indicated by (-), where staining was ... Although the expression of iNOS in porcine ovaries is well known, our findings contrast in part with the previous report [12] In the present study, iNOS was mainly localized to the oocytes of unilaminar ... study revealed that three isoforms of NOS were expressed in the porcine ovary, suggesting that nitric oxide might be involved in the process of follicular development and/or the ovulatory process...
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