Composite controlled release system of nitric oxide for cardiovascular tissue engineering application

... COMPOSITE CONTROLLED RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE ... illustration of the proposed composite controlled release system of NO is depicted in Figure 1-1 There are three main parts in the composite system: supportiv...

Ngày tải lên: 10/09/2015, 09:08

... tissue engineering application This thesis reports on a novel hybrid nanofibrous PCL membrane scaffold for cardiovascular tissue engineering application, achieved by surface modification of the PCL ... methods in nanofibrous surface modification of PCL membrane are presented in details Ultra- thin PCL membrane was prepared via 2-rollheated-mill,...

Ngày tải lên: 26/11/2015, 22:40

... (lateral collateral ligament and medial collateral ligament) , and two interior ligaments (anterior cruciate ligament (ACL) and posterior cruciate ligament) , which help control stabilisation and ... Rotating Wall Bioreactor 28 2.2.2.3 The Flow Perfusion Bioreactor 29 CHAPTER 3: DESIGN AND FABRICATION OF BIAXIAL MECHANICAL STIMULATION AND PERFUSION BIOREACTOR 32 3....

Ngày tải lên: 04/10/2015, 10:25

... tighter binding of cadmium than zinc in metallothioneins and the preference of zinc in the more flexible b-domain In addition to the already described differences in flexibility of the b-domain in MT ... reported increased metal release in the presence of oxidized glutathione (GSSG) and even slightly tighter metal binding under the in uence of reduced...

Ngày tải lên: 07/03/2014, 15:20

... morphological criteria The murine macrophage cell line RAW264.7, originally from the American Type Culture Collection (Manassas, VA, USA) and maintained in our laboratory, was also used For cell ... antibody pairs A 96-well EIA/RIA plate (Corning Inc.), coated with a coating antibody and masked with skim milk, was incubated with test samples and standard solutions A biotin...

Ngày tải lên: 17/03/2014, 10:20

... d) after 12 days in Ha Long Bay area: a, b - SE wind, c, d - NE wind Development of system of hydrodynamic-environmental models for coastal area 65 The field sampling results in September 2005 ... 1/2003, pp 10 8-1 13 (in Vietnamese) [7] Dinh Van Uu et al (2005), Application of the 3D water circulation model for studying SPM transport processes in Quang...

Ngày tải lên: 13/02/2014, 12:20

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inh...

Ngày tải lên: 22/02/2014, 04:20

... isoforms of NOS with CaM-TnC chimeras demonstrated that the roles of the four EF hands in the binding and activation of the cNOS and iNOS enzymes are distinct [13] Replacement of any CaM EF hand ... enzymes during binding and activation [4,5] The present investigation, designed to further assess the role of the two CaM EF hand pairs in the binding and...

Ngày tải lên: 16/03/2014, 13:20

... Ca2+ Degradation of NOS isozymes by calpain binding capacity of calpain The physiological relevance of this novel property of HSP90 is also discussed Results Degradation of NOS isozymes in Ca2+ ... intracellular localization of the synthase Degradation of NOS isozymes by calpain The physiological relevance of these findings becomes particularly evide...

Ngày tải lên: 23/03/2014, 07:20

... hydrophobic anchors Given the length of the first helix of cupiennin 1a, and the number of hydrophobic anchors available, it seems likely that the cupiennin 1a ⁄ Ca2+-CaM complex is analogous to the structure ... that cupiennin 1a also complexes with Ca2+-CaM, and is one of the more active of the known peptide inhibitors of nNOS Cupiennin 1a from Cupi...

Ngày tải lên: 23/03/2014, 09:21

... In vivo degradation of NOS and HSP90 by calpain M Averna et al Table Levels of native and 15 kDa calpastatin species in brain and aorta of NMS and HMS rats treated with HSD for weeks The data ... compilation ª 2008 FEBS M Averna et al In vivo degradation of NOS and HSP90 by calpain higher than in aorta, resulting in a much higher HSP90 to NOS ra...

Ngày tải lên: 30/03/2014, 04:20

... in the human brain after fatal head injury J Neurotrauma 2002, 19:279-84 Macdonald NJ, Taglialatela G: Tumor necrosis factor alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma ... Cuzzocrea S: Inhibition of the nuclear factor- kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spin...

Ngày tải lên: 19/06/2014, 22:20

... Motivated by the work of Combettes and Hirstoaga 34 in a Hilbert space and Takahashi and Zembayashi 33 in a Banach space, Zhang 35 and also authors of 36 obtained the following lemma Lemma 2.2 see 35 ... Saewan and P Kumam, A hybrid iterative scheme for a maximal monotone operator and two countable families of relatively quasi-nonexpansive mappings for ge...

Ngày tải lên: 21/06/2014, 07:20

... the Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 13 appropriate biotinylated second antibody and the avidinbiotin peroxidase ... der Valk, P Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating mult...

Ngày tải lên: 07/08/2014, 14:22

... localization of neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms of nitric oxide synthase (NOS) in the ovaries of pigs The intensity of staining is indicated by (-), where staining was ... Although the expression of iNOS in porcine ovaries is well known, our findings contrast in part with the previous report [12] In the present study, iN...

Ngày tải lên: 07/08/2014, 18:21