Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... develop and apply computational methods and tools for ADR and toxicity prediction The methods developed in this work are potentially useful for development and application of QSAR models as well ... complex, time consuming and resource intensive Toxicity is one of the primary reasons for the failure of drug candidates in later stages of drug deve...
Ngày tải lên: 10/09/2015, 09:02
Báo cáo y học: "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon" ppsx
... (and Lys) tend to be over- High density IJISS DNA arrays have been developed for global analysis of Streptomyces gene expression and transcription factor binding The HspR regulatory system of S ... against the test arrays and the probe performance was scored using the following equations Firstly the Cy3 and Cy5 background-subtracted signals, designated 'g' an...
Ngày tải lên: 14/08/2014, 21:20
development and application of mixed beam-solid models for analysis of soil-pile interaction problems
Ngày tải lên: 14/11/2014, 12:55
Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
... αglucosidase and α-amylase can significantly reduce the post-prandial increase in blood glucose after a meal, with starch as the major calorie intake The apparent advantage of the starch hydrolase inhibitors ... linear range of gelatinized starch Table Accuracy and precision of the high- throughput method Table IC50 and acarbose equivalence of inhibitors obtaine...
Ngày tải lên: 10/09/2015, 09:01
Development and application of novel capillary electrophoresis techniques for analysis of DNA fragments and organic pollutants
... focused on the analysis of DNA fragments; and the second part (chapter and chapter 5) focused on the analysis of organic pollutants Several novel capillary electrophoresis (CE) techniques had ... various applications, the CE applications in DNA analysis and monitoring of pollutants are of significant importance 1.3.1 CE Application in DNA Analysis...
Ngày tải lên: 14/09/2015, 11:40
Application of computational intelligence for faulty detection and diagnosis of induction motors and electromechanical systems
... automatic software platform for fault detection and diagnosis of induction motors and electromechanical systems, analyzing vibration data features and studying and comparing related algorithm, and targeting ... APPLICATION OF COMPUTATIONAL INTELLIGENCE FOR FAULT DETECTION AND DIAGNOSIS OF INDUCTION MOTORS AND ELECTROMECHANICAL SYSTEMS ZHANG...
Ngày tải lên: 30/09/2015, 13:41
Tài liệu Báo cáo khoa học: Application of a fluorescent cobalamin analogue for analysis of the binding kinetics A study employing recombinant human transcobalamin and intrinsic factor pdf
... Expression and purication of human recombinant IF and TC The recombinant Cbl binding proteins and their fragments were isolated from plants and yeast as described earlier [9,17] Preparation of the unsaturated ... Fedosova NU, Nexo E & Petersen TE (2002) Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, tran...
Ngày tải lên: 19/02/2014, 05:20
Fabrication and application of silicon nanowire transistor arrays for biomolecular detection
... and encapsulated using glass rings and a biocompatible epoxy glue Please cite this article in press as: X.T Vu, et al., Fabrication and application of silicon nanowire transistor arrays for biomolecular ... et al., Fabrication and application of silicon nanowire transistor arrays for biomolecular detection, Sens Actuators B: Chem (2009), doi:10.101...
Ngày tải lên: 16/03/2014, 15:24
Preparation, characterization and application of heterogeneous solid base catalyst for biodiesel production from soybean oil
... performances of these acid catalysts are still inferior compared with the base catalysts For this reason, a wide variety of solid bases have been examined for transesterification reactions for biodiesel ... of used vegetable oils using the heterogeneous WO3/ZrO2 catalyst for production of biodiesel Bioresour Technol 2010;101:S59e61 [10] Lou WY, Zong MH, Duan ZQ Ef...
Ngày tải lên: 05/05/2014, 08:42
Development of computational methods for the rapid determination of NMR resonance assignment of large proteins
... determination is the spectral assignment procedure This involves sequence-specific resonance assignment of NMR signals and the assignment of NOESY spectra Resonance assignment forms the basis for characterizing ... obtain the assignments of the Cα and CO of the same residue Then, the CO frequency is used to obtain assignments for the HN and 15N of...
Ngày tải lên: 04/10/2015, 15:52
Application of computational intelligence in biological sciences
... and constraints, the searching of these probes using traditional searching methods is computationally intensive Our approach is to use make use of computational intelligence techniques, in this ... target In a probe, if one section of the ORF is 31 E n d -p o in t of s u b -s e q u e nc e Chapter Finding Probes of Yeast Genome using ES Start-point of sub-sequence Figure...
Ngày tải lên: 30/09/2015, 13:41
báo cáo khoa học:" Study on the clinical application of pulsed DC magnetic technology for tracking of intraoperative head motion during frameless stereotaxy" pdf
... 2:10 http://www .head- face-med.com/content/2/1/10 Figure1 Type B fixation of the head Type B1 fixation of the head (A) Patient positioned on the right side for resection of a left frontal metastasis ... chosen on the basis of the image data Accuracy of frameless stereotaxy with the DRF in the clinical application The overall precision of the DRF...
Ngày tải lên: 11/08/2014, 23:22
application of committee k-nn classifiers for gene expression profile classification
... APPLICATION OF COMMITTEE k-NN CLASSIFIERS FOR GENE EXPRESSION PROFILE CLASSIFICATION Manik Dhawan Thesis Approved: Accepted: _ Advisor Dr Zhong-Hui Duan _ Dean of ... informative genes to feed a series of k-NN classifiers each having a different architecture Recruit the top performing k-NN classifiers to form a committee Evaluate the k-NN classifier based...
Ngày tải lên: 30/10/2014, 20:03
application of real coded genetic algorithm for ship hull surface fitting with a single non-uniform b-spline surface
... Pukyong National University August 2009 Application of Real Coded Genetic Algorithm for Ship Hull Surface Fitting With a Single Non-Uniform B-spline Surface A dissertation by Tat-Hien Le Approved ... data of container ship (included vertices and knot values) 93 viii Application of Real Coded Genetic Algorithm for Ship Hull Surface F...
Ngày tải lên: 13/11/2014, 08:18
Study on application of high k dielectric materials for discrete charge storage memory
... investigation Another exploration of high- k dielectrics for SONOS type memory is to use highk dielectrics as charge storage layer instead of nitride The potential advantages of high- k charge storage ... the formation of NCs, device integration, and the memory performance The implementation of high- k dielectric instead of SiO2 brings additional advantage...
Ngày tải lên: 14/09/2015, 13:32