Hydrogen sulfide and neurogenic inflammation in a murine model of polymicrobial sepsis

... established as a novel mediator of inflammation It has been demonstrated to play a pro-inflammatory role in animal models of local and systemic inflammation, including carrageenan-induced hindpaw ... 3-mercaptopyruvate sulfurtransferase AC adenylyl cyclase AECOPD Acute exarcebation of chronic obsructive pulmonary disease ALI Acute lung injury ALT Alanine aminotransferase ANOV...

Ngày tải lên: 10/09/2015, 08:32

... appearance of "mature" amyloid plaques [26,30] These plaques contain fibrillar amyloid peptide and as such can be detected by thioflavine, a reagent that stains proteins in beta sheet conformation ... with oligo A or fAβ Characteristic of fibrillar amyloid plaques in both human AD brain and in mouse models of amyloid accumulation is robust association of activated ast...

Ngày tải lên: 19/06/2014, 22:20

... frequently employ autoantigen microarrays as a screening tool to identify autoantibody reactivities using a multiplex platform and rely heavily on statistical algorithms to determine significant differences ... TLR inhibitors are already being tested in SLE in early-phase human clinical trials Our studies provide a crucial link between the IFN -I system and TLR signaling in...

Ngày tải lên: 09/08/2014, 14:22

... airway inflammatory diseases Therapeutic targeting of LPA2 may be beneficial in reducing allergic inflammatory responses in airway diseases Competing interests The authors declare that they have ... 279(39):41085-41094 Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, Momose K: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid- induced...

Ngày tải lên: 12/08/2014, 14:20

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên: 18/06/2014, 19:20

... murine brain: (1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of ... used as internal control and untreated control animals (n = 10) were analyzed for baseline evaluation of intracerebral cytokine profiles in these mice (2) In the...

Ngày tải lên: 19/06/2014, 22:20

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên: 20/06/2014, 03:20

... 5'-GCCTCCAGCATGAAAGTCTC, 3'-TAAAACAGGGTGTCTGGGGA), IL-1β (5'-TGCACGATGCACCTGTACGA, 3'-AGGCCCAAGGCCACAGGTAT), IL-6 (5'-GTTCCTGCAGAAAAAGGCAAAG, 3'-CTGAGGTGCCCATGCTACATTT), matrix metalloproteinase (MMP)-3 ... DHMEQ inhibits TNF-α-induced nuclear translocation of NF-κB, and does not inhibit phosphorylation and degradation of IκB, or a c-Jun N-terminal kinase (JNK) and a caspase...

Ngày tải lên: 09/08/2014, 07:20

... to a number of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained ... increase the affinity of the DNase I for DNA, resulting in two improved characteristics – increased specific activity compared to the wild-type enzyme a...

Ngày tải lên: 09/08/2014, 07:20

... Homma Y, Kawakami Y: Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma Thorax 2001, 56:19-24 30 Tamaoki J, Tagaya E, Kawatani ... Efficacy of inhaled corticosteroids in asthma The Journal of allergy and clinical immunology 1998, 102:531-538 29 Kamachi A, Munakata M, Nasuhara Y, Nishimura M, Ohtsuka Y, Ami...

Ngày tải lên: 12/08/2014, 11:20

... smoke-induced airway neutrophilia was attenuated by a dual tachykinin NK1/ NK2 receptor antagonist in guinea pigs [22] The purpose of this study was to characterize the precise role of the tachykinin ... whereby a role for the tachykinin NK1 receptor in macrophage and DCs accumulation was demonstrated The impaired accumulation of these cell types see...

Ngày tải lên: 12/08/2014, 14:20

... bronchial inflammation and airway hyperreactivity in mice Pharmacology 1997, 55:32-43 Satoh Y, Kasama K, Kuwabara M, Yimin, Diao HY, Nakajima H, Kohanawa M, Minagawa T: Suppression of late asthmatic ... after CpG treatment in a murine model of allergic inflammation Our results indicate that induction of Th1 response by therapy with CpG- ODN is partially depende...

Ngày tải lên: 12/08/2014, 18:21

... function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, caspase- 11 and caspase- 12 ) ... caspase- 1 to an influenza A/ Puerto Rico/8/34 (H1N1) virus infection of RAW264.7 murine macrophages, in vitro To investigate the role of ca...

Ngày tải lên: 13/10/2015, 16:41

... 1: faint staining; 2: small amount or weak staining; 3: moderate staining; 4: abundant or strong staining; 5: Abundant or very strong staining Means for each group were determined using the individual ... immediately following ablation Panels f-l are CD3+ stained tumor sections from LA treated animals collected at day post treatment Panels f and g depict CD3+ staining of a vascular la...

Ngày tải lên: 18/06/2014, 19:20

... this article as: Virgili et al.: Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis Journal of Neuroinflammation 2011 ... by diazoxide treatment We conclude that oral administration of diazoxide constitutes an appropriate therapeutic approach for treating MS and other de...

Ngày tải lên: 19/06/2014, 22:20