Virtual screening of multi target agents by combinatorial machine learning methods
Virtual screening of multi target agents by combinatorial machine learning methods
... Application of Combinatorial Machine Learning Methods in Virtual Screening of Selective Multi- target Antidepressant Agents 94 5.1 Introduction 94 5.2 Materials and Methods ... facilitating multi- target drug discovery 142 6.1.2 Findings of combinatorial machine learning methods for virtual screening in the multi- target kinase inhibitors and antide...
Ngày tải lên: 09/09/2015, 18:53
Methods to improve virtual screening of potential drug leads for specific pharmacodynamic and toxicological properties
... validation of QSAR The various approaches examined are useful, to varying extents, for improving the virtual screening of potential drug leads for specific pharmacodynamic and toxicological properties ... improvement of virtual screening for specific pharmacodynamic and toxicological properties Limitations of the completed projects and potential...
Ngày tải lên: 10/09/2015, 08:34
Báo cáo khoa học: "Extraction of definitions using grammar-enhanced machine learning" pdf
... either only machine learning or only a grammar and not a combination of the two and (2) they not distinguish different definition types The advantage of using a combination of a grammar and machine ... properties Thereafter, machine learning methods are applied on the set of candidate definitions to distinguish definitions from non -definitions; to this end a combination of...
Ngày tải lên: 08/03/2014, 21:20
Báo cáo y học: "Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer" potx
... ture of RITA and to improve the activity of a new family of potent anti-cancer drugs Conclusion The aim of the present study was to support the viability of the multi-target approach in the design ... observed by these compounds would compensate their therapeutic deficiencies because of the dynamic nature of the targets involved and the observed promisc...
Ngày tải lên: 13/08/2014, 23:20
Development of virtual screening and in silico biomarker identification model for pharmaceutical agents
... based virtual screening 1.3.2 Machine learning methods for virtual screening 12 1.3.3 Virtual screening for subtype-selective pharmaceutic agents 15 1.4 Bioinformatics tools in biomarker ... Development of Virtual Screening and In Silico Biomarker Identification Model for Pharmaceutical Agents ZHANG JINGXIAN (B.Sc & M.Sc., Xiamen University) A T...
Ngày tải lên: 09/09/2015, 10:06
DIRECT TREATMENT OF POLLUTED RIVER WATER BY THE MULTI-SOIL-LAYERING METHOD
... suspended solids (SS) by Standard Method for the Examination of Water and Wastewater (1995), COD by potassium dichromate method, NH4-N by Nessler method, NO2-N by diazotization method, NO3-N and ... water was discharged from houses In spite of such fluctuation of BOD in river water, the BOD concentration of treated water was very small in all the MSL system...
Ngày tải lên: 05/09/2013, 08:40
Tài liệu ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 docx
... Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER ... Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR...
Ngày tải lên: 16/02/2014, 10:20
Báo cáo khoa học: Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library pdf
... appeared By comparison with the spectrum of N1-liganded GABARAP (A) , these resonance signals can be attributed to N1-liganded GABARAP By binding to GABARAP, N1 peptide displaces CRT from GABARAP A few ... A dissociation constant of 64 nm for the GABARAP CRT interaction was Calreticulin is a high affinity ligand for GABARAP Fig Homology model of CRT(1–332) with...
Ngày tải lên: 16/03/2014, 05:20
ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR GOVERNMENTAL AFFAIRS AGENTS BY REGISTRATION NUMBER FOR THE SECOND QUARTER 2005 potx
... County of Essex 365 County of Hudson 849 Page 18 of 75 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR GOVERNMENTAL AFFAIRS AGENTS BY REGISTRATION NUMBER FOR THE SECOND QUARTER 2005 ... Humane Society of the US 711 Page 29 of 75 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR GOVERNMENTAL AF...
Ngày tải lên: 22/03/2014, 21:20
Báo cáo khoa học: Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening doc
... permitting the selection of full-length IgGs from libraries displayed on phage We believe that sequential selection by phage display and then FACS enables the efficient screening of very large ... IgG libraries can be displayed on phage particles and undergo selection, we sought to develop a display system that will effectively display intact IgGs on...
Ngày tải lên: 22/03/2014, 21:21
Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt
... gels of purified recombinant SR (left) and the PDZ6 domain of GRIP (middle) The circular dichroism spectrum of purified PDZ6 domain of GRIP is shown in the right panel (C) D -Serine synthesis by recombinant ... Characterization of SR activation by the PDZ4-PDZ5-PDZ6GAP2-PDZ7-end module of GRIP D -Serine synthesis by recombinant SR in the presence of incre...
Ngày tải lên: 30/03/2014, 03:20
Báo cáo khoa học: "Machine Translation by Triangulation: Making Effective Use of Multi-Parallel Corpora" pptx
... The lexical translation score is used for smoothing the phrase-table translation estimate This represents the translation probability of a phrase when it is decomposed into a series of independent ... greater generalisation, since the translation distribution is estimated from a richer set of data-points For example, instances of the Danish en varm kartoffel may be used to tra...
Ngày tải lên: 31/03/2014, 01:20
Báo cáo hóa học: " Testing the potential of a virtual reality neurorehabilitation system during performance of observation, imagery and imitation of motor actions recorded by wireless functional nearinfrared spectroscopy (fNIRS)" potx
... this article as: Holper et al.: Testing the potential of a virtual reality neurorehabilitation system during performance of observation, imagery and imitation of motor actions recorded by wireless ... execution (as in traditional motor learning), imitation, observation (as in observational learning) and motor imagery Activation of these b...
Ngày tải lên: 19/06/2014, 08:20
Báo cáo hóa học: " Synthesis of multi-walled carbon nanotube/ polyhedral oligomeric silsesquioxane nanohybrid by utilizing click chemistry" pptx
... multiwalled carbon nanotubes Macromolecules 2009, 42:5416 doi:10.1186/1556-276X-6-122 Cite this article as: Yadav et al.: Synthesis of multi-walled carbon nanotube /polyhedral oligomeric silsesquioxane nanohybrid ... spectra of nanohybrid (a) TEM images of MWNT-POSS nanohybrid and (b) EDX spectra of MWNTPOSS nanohybrid Furthermore, XPS was additionally used to inv...
Ngày tải lên: 21/06/2014, 05:20
Báo cáo hóa học: " Effects of Gas Composition on Highly Efficient Surface Modification of Multi-Walled Carbon Nanotubes by Cation Treatment" pptx
... correlates with the composition of the generated cations In this study, the effect of gas composition on the functionalization process is investigated, by providing various H2/O2 gas mixtures to ... most effective gas mixture to graft oxygen-containing functional groups and remove the amorphous carbon on the surface of the nanotubes Specifically, by using this ga...
Ngày tải lên: 22/06/2014, 01:20