... 12 Phosphatidylinositol 3,4,5-trisphosphate levels in mouse embryonic fibroblasts cloning of rat SH2-containing inositol phosphatase (SHIP2) and its role in the regulation of insulin signaling ... Blero et al Phosphatidylinositol 3,4,5-trisphosphate levels in mouse embryonic fibroblasts phosphorylation [9] As phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] is a major intracellular ... homology 2-containing inositol 5¢-phosphatase via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors Mol Endocrinol 16,...