Investigations on the immunopathology of enterovirus 71 5
Investigations on the immunopathology of enterovirus 71 1
... of EV 71 strains 18 4 CHAPTER CONCLUSION AND FUTURE WORK 19 2 7 .1 ROLE OF INTERLEUKIN-6 IN THE IMMUNOPATHOGENESIS OF EV 71 INFECTION 19 2 7.2 ROLE OF DC IN EV 71 INFECTION ... Distribution of EV 71 isolates identified globally from 19 70 to 2000 16 Figure 1. 4 Distribution of inflammation in brain sections of EV 71 patients 23 Figure 1. 5 The postulated pathol...
Investigations on the immunopathology of enterovirus 71 3
... percentage composition per spleen The dotted line indicates the highest amount or percentage of cells observed for the two fatal strains (B) Specific anti-EV71 IgM and IgG titers in sera of infected ... CHAPTER INVESTIGATIONS ON EV71 VIRULENT DETERMINANTS B Figure 6.5 Adaptive immune response in EV71-infected AG129 mice (A) Two-week-old mice were infected ... (n=5) were euthaniz...
Investigations on the immunopathology of enterovirus 71 2
... well as the effects of the systemic inflammatory response on the vascular endothelium The key to further decipher the exact mechanisms for PE in EV71 encephalitis relies on the development of more ... observed (Shieh et al, 20 01; Yang et al, 20 09) 22 CHAPTER LITERATURE REVIEW Figure 1.4 Distribution of inflammation in brain sections of EV71 patients (A) Whole brai...
Investigations on the immunopathology of enterovirus 71 4
... CHAPTER CONCLUSION One limitation of the present study is the use of neonatal mice as animal model IL-6 functions mainly as the inducer of acute-phase response and T- and B-cell stimulation Given the ... throughout the course of infection While we could not entirely rule out the contribution of myositis to EV71-induced disease manifestations, our results suggest that th...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the s...
Investigations on the toxicity of nanoparticles
... + Oxidationm-n- 1.3 Equation 1.3 depends on the thermodynamics of the process, which in turn is represented by the electrochemical potentials of the corresponding half cell reactions These are ... stability of the particles Agglomeration of the nanoparticles will yield particles of size in the micron range, skewing data interpretation The commercially available...
Báo cáo khoa học: Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family ppt
... interacts with the backbone nitrogen of < /b> Ser71 as seen for the O2 interaction in R5P As for O1 of < /b> R5P, the terminal group of < /b> the inhibitor has hydrogen bonds to Asn103¢ and the backbone nitrogen of < /b> Gly74; ... arise from the slightly broader active site in MtRpiB as a result of < /b> the switch of < /b> the catalytic base Accordingly, the lo...
Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... vertebrates In conclusion, there is a single, large, evolutionarily conserved protrusion on the surface of the catalytic domain of PCSK9 The lack of other residue conservation on the PCSK9 surface ... of the mutants S15 3A -PCSK9, Q19 0A -PCSK9, R19 4A -PCSK9, D20 4A -PCSK9, K22 2A -PCSK9, R23 7A -PCSK9, D23 8A -PCSK9, D37 4A -PCSK9, C37 5A -PCSK9, S37...
study on the etiology of acute respiratory infection in children under 5 years old in nhatrang, 2009
... respiratory infections among children under years old in Nha Trang City, 2009 OBJECTIVES OF THE STUDY Identifing the fundamental limits of some causes of ARI among children under years old Identifing the ... under 5- year -old children 3.2.1.1 Findings from determining bacteria in under 5- year -old healthy children: Table 3.4 Findings from dete...
Investigations on the cellular and neuroprotective functions of nogo AReticulon 4a
... by Nogo- A expression The same effects are also observed by Nogo- B expression On the other hand, while Nogo- C and RTN3 confer some degree of protection against serum deprivation, staurosporine and ... in the inhibition of neurite outgrowth 1.2 Molecular characterization of Nogo- A 1.2.1 Nogo: part of the Reticulon family Identification and characterization of...
Investigations on the antiplasmodial activity of ferrocenyl chalcones
... activity of ferrocenyl chalcones The other physicochemical properties of the ferrocenyl chalcones should be considered together with their oxidant potential In conclusion, the study has shown that ferrocenyl ... Chemical Considerations 3.3.1 Synthesis of ferrocenyl chalcones The syntheses of the two series of ferrocenyl chalcones proceeded by basecataly...