Using biological networks and gene expression profiles for the analysis of diseases

... Using Biological Networks and Gene- Expression Profiles for the Analysis of Diseases LIM JUNLIANG KEVIN (B.Comp (Hons.), NUS) A DOCTORAL THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... some of these problems by incorporating biological information into their framework in the form of gene sets These gene sets represent biological processes...

Ngày tải lên: 09/09/2015, 10:15

... vs atypical AP Comparison Category Term Typical vs Ctrl Typical vs Ctrl Typical vs Ctrl Typical vs Ctrl Typical vs Ctrl Atypical vs Ctrl Atypical vs Ctrl Atypical vs Ctrl Atypical vs Ctrl Atypical ... we only investigated gene expression profiles in the liver, it is possible that these genes may be affected by both typical APs and atypical APs in other...

Ngày tải lên: 11/08/2014, 17:20

... family, the miR-200 family have been reported in human [16,17] and mouse embryonic stem cells [18-20] The unique patterns of miRNA expression in embryonic stem cells suggest they are involved in maintaining ... instance, miR-373 induces the expression of E-cadherin and CSDC2 by targeting their promoter region and initiate their expression[ 73] Another me...

Ngày tải lên: 18/06/2014, 15:20

... process of rheumatoid synovitis In this study, we analyzed gene-expression profiles in proliferative lesions of the synovial lining tissues in early RA using targeted biopsy of synovial tissues and ... arthroscopy, and analyzed gene-expression profiles in the synovial lining tissues selected by LCM in a cDNA microarray by comparing those in multilayer...

Ngày tải lên: 09/08/2014, 06:23

... calculated by dividing the mean intensity signal from all the individual SCWinjected rats included in each group by the mean intensity signal from the corresponding PBS control group The level ... for the time Schematic representation of themodel of streptococcal cell wall course study in the reactivation model of streptococcal cell wall (SCW)-induced arthritis...

Ngày tải lên: 09/08/2014, 06:22

... ARTICLE Open Access Structure and expression of the maize (Zea mays L.) SUN- domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants Shaun P Murphy1, ... previously unknown class of SUN- related proteins in plants mRNA Expression Profiling of ZmSUN Protein Genes The conservation...

Ngày tải lên: 11/08/2014, 11:21

... Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues Genetics Selection Evolution 2011 43:28 Submit your next manuscript to BioMed Central and take ... between gene expression profiles in five endocrine tissues and plasma metabolites in pigs The associations were found to be highly tissuespecific, a...

Ngày tải lên: 14/08/2014, 13:21

... schematic overview of database generation in relation to the NCI drug discovery program Each row of the activity database (A) represents the pattern of activity of a particular high-concentration ... (http://dtp.nci.nih.gov) The union of Tr and was 5.72 with an interquartile range of Ti (as well as a protein database not considered here28) constitutes an overall...

Ngày tải lên: 30/03/2014, 13:20

... and health status, use of self-care and self-care support, and a set of validated measures on aspects of social capital and social support A second survey instrument was administered and audio-recorded ... Trusts and the University of Manchester and is part of the National Institute for Health Research The authors are members of the Patient Them...

Ngày tải lên: 10/08/2014, 10:23

... protein sequences from spruce and pine Alignment of predicted MYB domain protein sequences from spruce and pine Amino acid sequence alignments of the 21 conifer MYB R2R3 domains were obtained with ... Isolation and sequence analysis of 18 R2R3-MYB genes from spruce and pine We isolated and sequenced 18 full-length cDNAs encoding R2R3-MYB genes from conifer tr...

Ngày tải lên: 12/08/2014, 05:20

... content of rat lungs Hydroxyproline content of rat lungs There was no significant difference in the hydroxyproline content of the four groups at days after instillation The hydroxyproline content of ... obviously by Lv-shCD36 Accordingly, CD36 may participate in the activation process of L-TGFβ1 in the early phase of the experimental silicosis Furthermore, si...

Ngày tải lên: 12/08/2014, 14:20

... first rank the expression of each gene across a series of experiments [11,16,17] This will facilitate the analysis of individual datasets of interest from the vast repository of gene expression ... conservation of miRNAs and their target genes between mice and humans and the accuracy of the RT-PCR measurements Some of those miRNAs with a significant effec...

Ngày tải lên: 14/08/2014, 08:21

... (99%) of the data from a negative control The gradual nature of these types of responses supports the use of regression analysis Because the effect may deviate from linearity in the range of perturbations ... cleaning up of the data, removal of systematic biases and drifts (a process often referred to as 'normalization'), and transformation to a format and sc...

Ngày tải lên: 14/08/2014, 17:22

... port cities Experimental analysis and modellistic evaluation carried on within APICE project were preceded by a comparative evaluation of the air quality  pollution in the port cities   involved ... devoted to the discussion of the results of the intercomparison campaign held in Marseille in February 2011 In addition, the recent developments of the common approa...

Ngày tải lên: 17/02/2014, 22:20

... insertion of the sample into the UHV chamber in spite of the preceding HF-dip There are hints in the literature [11 ] that deposition of gold onto a thin layer of SiO2 on Si (1 1) favors the decomposition ... melting point (15 7 1C) [13 ] As the surface tension of most liquids decreases in a nearly linear fashion with increasing temperature [14 ], there is...

Ngày tải lên: 16/03/2014, 15:17