SELF ASSEMBLY AND DRUG DELIVERY IN AMPHIPHILIC PEPTIDES MICROSCOPIC INSIGHTS FROM COARSE GRAINED SIMULATIONS

... microscopic insights into the self- assembly of amphiphilic peptides, and the loading and release of drug are provided Equilibrium and dynamic properties are obtained from a molecular level Key governing ... amphiphilic peptides from a microscopic scale, elucidate the detailed process of drug loading and release, and provide bottom-up guidelines towards the i...

Ngày tải lên: 09/09/2015, 08:13

... information of the role of aromatic moieties in amyloid fibril formation [36–41] A parameter-free model based on the mathematical analysis of many peptide fragments and their analogues had clearly ... short fragments, such as the pentapeptide fragments of the human calcitonin peptide and IAPP (Table 1), rapidly and efficiently form typical amyloid fibrils Despite ha...

Ngày tải lên: 23/03/2014, 11:20

... = 100 μm intranasal drug delivery helps in improving the efficacy of drug by assisting in its lung delivery and biodistribution The PLGA- PEGPS341 provides controlled and targeted drug delivery ... drug- delivery therapeutics for CF and other airway diseases like COPD and asthma The nanodrug delivery system here provides controlled and sustained PS-34...

Ngày tải lên: 11/08/2014, 00:22

... single cysteine mutations, and demonstrated that this helix plays a prominent role in the coupling process in ABCB1 [25–28] A number of mutations in TM6 caused alterations in drug- stimulated ATP ... Catalytic intermediate CM BM FM Basal AMP-PNP Vi trapped Basal AMP-PNP Vi trapped Basal AMP-PNP Vi trapped Basal AMP-PNP Vi trapped Basal AMP-PNP Vi trapped Basal AMP-PNP...

Ngày tải lên: 06/03/2014, 22:21

... self-disclosure depending on various relationship strength metrics The x axis shows relationship strength according to tweeting behavior (chain frequency and chain length), and the y axis shows ... of initial getting-to-know conversations in Twitter They welcome and greet each other about kids and pets, and offer sympathies about feeling bad One interesting way to use ou...

Ngày tải lên: 30/03/2014, 17:20

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Ngày tải lên: 01/06/2014, 14:03

... Discussion Summary of main findings Both health- related problems and alcohol intoxications in early adolescence showed influence on frequent alcohol use and initiation of illegal drugs years later, ... behavioural and health problems on late adolescence regular drinking and drug use To explore the impact of gender and early drinking on the r...

Ngày tải lên: 13/08/2014, 18:21

... characterization and understanding of the self- assembly in amphiphilic block copolymers A B Figure 1.1 Schematic representation of AB diblock copolymer forming micelle in a selective solvent Block copolymers ... formation of micelles (microphase separation) with B blocks 17 Chapter forming the core of the micelle and A blocks forming the corona (Figure 1.1) Earlier stu...

Ngày tải lên: 09/09/2015, 11:25

... GROWTH AND PATTERNING OF NANOSTRUCTURES THROUGH IRREVERSIBLE LIQUID DRYING, SELF- ASSEMBLY, AND CRYSTALLIZATION WU JIHONG NATIONAL UNIVERSITY OF SINGAPORE 2010 ACKNOWLEDGEMENTS ... anthracene wires based on irreversible liquid drying and molecular self- assembly; and (4) macroscopic surface architectures of self- assembled (3-aminopropyl)triethoxysilane...

Ngày tải lên: 11/09/2015, 10:04

... rigid core exert hindrance to self- assembly whereas the pyrimidine groups stabilized the self- assembly of jacketed polymers A series of novel jacketed liquid crystalline polymers, in which the terphenyl ... expected to help the self- assembly of the polymers The length of the alkyl chain and position of the alkyl chain on the mesogenic units appears to have s...

Ngày tải lên: 16/09/2015, 17:11

... of polymers 3a, 3b and 3c were measured in chloroform solution The absorption and emission spectra of the polymers are shown in Fig .5. 3 and the values as given in Table 5. 2 The UV spectrum of ... = 5. 2Hz, CCH(O)-, H), 4 .5 (d, J = 5. 5 Hz, O-CH2-, H), 2.7 (s, -OH, H) 13 CNMR ( 75. 4 MHz, CDCl3, δ ppm) 154 .2, 137.2, 134.7, 127.7, 126.7, 126.0, 1 25. 7, 1 25. 5, 121.0,...

Ngày tải lên: 16/09/2015, 17:11

... CDCl3, δ ppm): 171, 149 .80, 149 .45 , 141 .17, 137.08, 136.62, 135.76, 1 34. 62, 1 34. 49, 133.79, 130.59, 129.33, 128.88, 126.63, 1 24. 90, 1 24. 07, 123 .45 , 113.72, 77.33, 76.91, 76 .48 , 69.11, 31.79, 30.79, ... 2θ1/° 2θ2/° 2θ3/° 2 4/ ° 2θ5/° d1(Å) d2(Å) d3(Å) d4(Å) d5(Å) 2 .46 2.86 P1(DBSA)0.5 3.02 20.1 P1 4. 91 7 .42 19.8 35.9 30.6 29 .4 17.9 11.9 4. 5 4. 4 The XRD diffraction pat...

Ngày tải lên: 16/09/2015, 17:11