Role of viral genetics in dengue epidemiological fitness

... underlying mechanisms of viral fitness in an epidemiological setting, however, remain poorly defined We conducted in vitro studies and identified a determinant of fitness in a foreign dominant ... ix List of tables x List of figures xi List of abbreviations xv List of publications xxi Chapter 1: An Introduction to the role of viral genetics in dengue epi...

Ngày tải lên: 09/09/2015, 08:12

... Retrovirology 2005, 2:41 Background The rate of HIV disease progression varies greatly among infected individuals, which is defined invariably by increasing plasma viral loads and concomitant decline in ... non-progressing donor A A, B and C, respectively (Figure 4) By incorporating a global molecular clock, constraining all branches with one single evolutionary rate, and l...

Ngày tải lên: 13/08/2014, 09:21

... in parameter values and Variations accumulated viral load their effect on the populaVariations in parameter values and their effect on the population-wide accumulated viral load Additional parameter ... The accumulated mean viral load, Av (t), in the population was the integral of the mean viral load from the beginning of a given simulation (time 0) until...

Ngày tải lên: 13/08/2014, 16:21

... during the acute phase of infection In conclusion, our findings provide new insight into the role of PTX3 in acute alphaviral infection The newly identified role of PTX3 in enhancing RRV infection ... PTX3 in Alphaviral Infection during acute alphaviral infections, we utilized an established RRVD mouse model [33 ] to examine the role of PTX3 during alphavirus inf...

Ngày tải lên: 22/09/2015, 15:19

... ethanol- regulated genes were involved using KEGG (Kyoto Encyclopedia of Genes and Genomes) [36] and GenMAPP (Gene Microarray Pathway Profiler) [37] analysis As shown in Table 2, only ITGB4 was found to be involved ... considering the reported high expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma Gankyrin binds to the cell-...

Ngày tải lên: 31/10/2012, 15:28

... in raising the profile of women in management or leadership roles Early leadership theories In the 18th and 19th centuries, philosophers suggested a theory of leadership which was termed the ... although the leadership literature has played a significant role in raising the profile of women in management, further advances are required in...

Ngày tải lên: 08/10/2013, 15:56

... globalization II Review of Institution Building in the Financial Sector A Main driving forces of institution building A review of the developments of China s financial sector over the past 20 years reveals ... unique role in institution building in the financial sector They help to mitigate financial repression in China, to establish sound...

Ngày tải lên: 18/10/2013, 07:15

... signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic drug ... abnormalities in microsomal drug- metabolizing function during the late phase of sepsis [6] However, the underlying mechanisms involved in hepatic dysfunction during sepsis...

Ngày tải lên: 14/02/2014, 18:20

... Atlanta, GA 30333 SUGGESTED CITATION Centers for Disease Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by ... Committee and the Advisory Committee for Elimination of Tuberculosis published a joint statement on the use of BCG va...

Ngày tải lên: 15/02/2014, 13:20

... Reserve therefore has a strong interest in understanding issues facing community banks I THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the ... While community banks still comprise the vast majority of banks, the question arises whether their role in the banking system has declined to the point...

Ngày tải lên: 16/02/2014, 11:20

... events from the origin of the wastewater to the consumption of the produce (e.g the farm-to-fork approach of the HAPPC method in food safety); • the design of a combination of health risk management ... Figure 19 in the timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lak...

Ngày tải lên: 17/02/2014, 10:20

... were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture medium was replaced every other day inside the chamber For miRNA transfection, ... were treated as described in (A) Total RNA was prepared at the indicated times and subjected to quantitative real-time PCR analysis The data shown are mean value ± standard err...

Ngày tải lên: 18/02/2014, 08:20

... Hallervorden–Spatz disease is a form of neurodegeneration caused by Table Genes associated with Lewy body inclusions and their role potential role in ceramide metabolism Gene Possibly ceramide metabolism; ... studies of this question have been published to date In this minireview, we have brought together data suggesting that some of the genes involved in the ge...

Ngày tải lên: 18/02/2014, 14:20

... 3821 Role of CerK in PPARb-induced keratinocyte survival K Tsuji et al Fig Schematic model illustrating the role of CerK in cell survival mediated by PPARb in mouse keratinocytes Under injury ... accumulation induced by serum starvation stress, which results in cell survival and inhibition of cell death in mouse keratinocytes Enhanced cell survival...

Ngày tải lên: 18/02/2014, 18:20