... overall fold of HCC-stab1 shows no significant differences when compared to the available models of type cystatins, such as chicken cystatin (PDB code: 1CEW), cystatin D (PDB code: 1RN7), or cystatin ... chicken cystatin or for human cystatin F [44], in which, respectively, a prominent a-helix or a helical coil is present (Fig 4C) Crystal packing and molecular interactions The HCC-stab1 molecules ... monomeric human cystatin D [43]; 1CEW, monomeric chicken cystatin [13]; 2CH9, monomeric human cystatin F [44]; 1STF, stefin B from papain complex [10]; 1NB5, stefin A from cathepsin H complex [11] HCC-stab1...