Coronary artery disease intervention considerations in elderly patients

... they even in the decision making process?? Cor Angio Treatment Methods Selection • Medical ? • Surgery? • Intervention? To intervene or not??? Coronary disease AAA Complex Trade-offs • Clinical ... pharmacodynamics and pharmacokinetics • • Decreased vascular compliance Increased myocardial stiffness -adrenergic responsiveness + impaired sinus node Decline in creatinine clearance, hepatic metabolism ... with invasive procedures Challenges in Evidence Based Medicine Community Trials Guidelines 60 68.3 Age Karen Alexander, DCRI Disease Severity Comorbidity Advanced CAD Elderly Excessive Dosing...

Báo cáo y học: "Efficacy of Sirolimus-Eluting Stents Compared With Paclitaxel-Eluting Stents in an Unselected Population With Coronary Artery Disease: 24-Month Outcomes of Patients in a Prospective Non-randomized Registry in Southern Turkey&

... departmental resources Abbreviations ACC: American College of Cardiology; AHA: American Heart Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse cardiac ... before initial and final angiograms to achieve maximal vasodilatation The use of glycoprotein IIb/IIIa inhibitor (Tirofiban) was at the operator’s discretion All patients maintained antiplatelet ... Goy JJ, Ulm K, et al Sirolimus-eluting stents vs paclitaxel-eluting stents in patients with coronary artery disease: meta-analysis of randomized trials JAMA 2005;294: 819-825 15 Roiron C, Sanchez...

antiplatelet response to aspirin and clopidogrel in patients with coronary artery disease undergoing percutaneous coronary intervention

... measuring response to aspirin and clopidogrel remains uncertain In light of this, the antiplatelet effects of both aspirin and clopidogrel were studied in patients with coronary artery disease, ... vitro administration of aspirin to help define aspirin ‘resistance’ (88) Dose of aspirin: The dosing of aspirin highlights one of the main difficulties with monitoring aspirin response in clinical ... response to aspirin (67) 1.5.1 Measuring response to aspirin in patients taking dual antiplatelet therapy In a study by Lev et al, aspirin response was measured prior to the introduction of clopidogrel...

Báo cáo y học: "Two-year Outcome of Turkish Patients Treated with Zotarolimus Versus Paclitaxel Eluting Stents in an Unselected Population with Coronary Artery Disease in the Real World: A Prospective Non-randomized Registry in Southern Turk

... results of these initial trials indicate that the ZES is safe and reduces the rates of clinical and angiographic restenosis in patients with symptomatic coronary artery disease (CAD; 4) Also the safety ... Abbreviations ACC: American College of Cardiology; AHA: American Heart Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse cardiac events; MI: myocardial infarction; ... between the ZES and the PES treated groups with the Kaplan-Meier method and log-rank test A P value < 0.05 was considered statistically significant RESULTS Baseline clinical, coronary angiographic and...

báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt

... this article as: Budzyński et al.: Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain A double-blind, ... outpatients with CAD-11 female (23%) and 37 male (77%)-diagnosed with recurrent stable angina-like chest pain refractory to standard anti-angina therapy and without indications for revascularization ... with omeprazole and the placebo prior to the study and after two weeks of therapy SF-36 scales Omeprazole (n = 23) Placebo (n = 25) At baseline After weeks At baseline After weeks Total average...

báo cáo khoa học: " A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol" doc

... cardiovascular; Atorva = atorvastatin; Prava = Pravastatin; Simva = simvastatin the EURopean trial On Reduction of cardiac events with Perindopril in stable coronary Artery disease (EUROPA)[34] and the ... with statin use (ALLHAT-LLT) was likely contaminated by very high rates of statin use in the "control" arm of that trial[ 15] A meta-analysis of these trials confirmed that statins are clearly beneficial ... MI, and treatment of unstable angina) A tenth trial evaluated the impact of a multifaceted intervention that included physician and nurse opinion leaders (as two of the 10 factors included in the...

báo cáo khoa học:" Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" docx

báo cáo hóa học:" Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study" potx

... visit and and treatment with ASA (A) , clopidogrel (C) and the combination of ASA and clopidogrel (A+ C) The respective figures show the effect of platelet inhibiting treatment on ADP-induced adhesion ... Cayman Chemical EIA Analysis Tools [http://www.cayman chem.com/analysis/eia] Bryman A, Cramer D: Aggregating variables Exploratory factor analysis In Quantitative Data Analysis with SPSS Release ... platelet activation as measured by flow cytometry (Factor 14) for patients (n = 29) (r2 = 0.49) Data included are from all three separate anti -platelet treatments (ASA and clopidogrel alone as...

Angiotensin-Converting– Enzyme Inhibition in Stable Coronary Artery Disease potx

... england journal of medicine original article Angiotensin-Converting Enzyme Inhibition in Stable Coronary Artery Disease The PEACE Trial Investigators* abstract background The writing committee for ... 56 Coronary disease on angiography 61 61 Angina pectoris 70 71 Percutaneous coronary intervention 42 41 Coronary- artery bypass grafting 38 40 Percutaneous coronary intervention or coronary- artery ... Angiotensin Converting Enzyme Inhibition Trial, HOPE the Heart Outcomes Prevention Evaluation, 15 and EUROPA the European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery...

Báo cáo y học: " Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study" pdf

... Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof -of- concept ... erythematosus, atherosclerosis, coronary artery disease, risk factors Introduction Systemic lupus erythematosus (SLE) is associated with a dramatically increased risk of atherosclerotic coronary artery disease ... were a total of 94 coronary events (75 angina, 25 MI and sudden cardiac deaths; had both angina and MI) in the BP dataset, while the TC dataset contained 86 coronary events (71 angina, 20 MI and...

GENOME WIDE ASSOCIATION STUDIES OF CORONARY ARTERY DISEASE IN SINGAPOREAN CHINESE POPULATIONS

... Singapore Coronary Artery Genetics Study xv SCES: Singapore Chinese Eye Study SCES: Singapore Chinese Eye Study SCHS: Singapore Chinese Health Study SiMES: Singapore Malay Eye Study SINDI: Singapore ... that studies of coronary artery disease in Asia are conducted to address this increasing burden 1.3 Overview of the etiology of coronary artery disease The etiology of CAD is multifactorial, involving ... findings 2.3.1 GWAS of CAD Genome wide association studies have identified multiple genetic variants associated with CAD Most of the associations have been replicated in independent studies, indicating...

The role of serum amyloid A1(SAA1) in coronary artery disease

... facilitating its growth and hence angiogenesis is pro-atherogenic The final stage in the development of an atheroma involves the rupturing of a plaque Plaque rupturing involves the erosion of the ... important for the binding of SAA1 to components of the extracellular matrix (Uhlar and Whitehead 1999) The only reported role of the C-terminal domain is its facilitation of the binding of SAA1 to ... on atherosclerosis In a study by Meek et al, mRNA of A-SAA was found in important components of the atherosclerotic lesion including endothelial cells lining the lumen of coronary artery, the...

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