... mammalian natriuretic peptide system, consisting of at least threeligands and three receptors, plays critical roles in health and disease. Exam-ination of genetically engineered animal models ... demonstrated in transgenic and knockout animal models. AbbreviationsANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; CNP, C-type natriuretic peptide; GC, guanylyl cyclase; MCIP1, ... selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130, 229–239.22 Steinhelper ME, Cochrane KL &...