... STZ-induced apoptotic death of RIN-m5F cells through the regulation of pro -apoptotic proteins These novel findings, taken together with previous observations, suggest that the anti -apoptotic effects of ... 10)6 m) Treatment of RIN-m5F with STZ resulted in the increased expression of pro -apoptotic Noxa and Bax mRNA and the suppressed expression of anti -apoptotic Bcl-2 and Bcl-XL mRNA However, PACAPs ... suppress the expression of Noxa mRNA and enhance Bcl-2 mRNA expression, leading to down -regulation of Bax mRNA Thus, PACAPs appear to be a potent regulatory element in the STZ-evoked apoptotic signaling...