Signal Transduction in Cancer

... similar effect in colon cancer Ordinarily, Wnt signaling via b-catenin (see Nusse 2012) maintains enterocytes in an undifferentiated state in colon crypts but is inactivated by APC-induced degradation ... pathways of signal transduction in cancer- associated processes, surveying the major signals involved and focusing on Ras-ERK and PI3K-Akt signaling to illustrate how their ta...

Ngày tải lên: 08/04/2015, 17:20

... this minireview is to summarize what is currently known about the molecular mechanisms of osmotic stress resistance, osmosensing and signal transduction in C elegans Osmosensing and signaling in ... process of interest, allows genes to be ordered into pathways, and can provide important and novel mechanistic insights into the molecular structure and functio...

Ngày tải lên: 30/03/2014, 03:20

... Arthritis Research & Therapy Vol No Ogawara et al as stress response, innate and adaptive immune reactions, and apoptosis [5-8] In endothelial cells, NF-κB is activated by inflammatory cytokines, ... To achieve selective gene transfer of dnIκB into endothelial cells, adenovirus can be used as a vector Infection by adenovirus is initiated by the high affinity binding o...

Ngày tải lên: 09/08/2014, 07:20

... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin ... the immunoglobulin heavy-chain locus Interestingly, Ikaros was found to bind at pericentromeric satellite DNA and could therefore play a role in the silencing of genes e...

Ngày tải lên: 14/08/2014, 20:22

... (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells Clin Cancer Res 11, ... little clinical benefit in the treatment of solid tumours and are now being tested in combination therapies [47] Tyrosine kinase inhibitors are widely and successfully...

Ngày tải lên: 29/03/2014, 08:20

... after its initial effect on protein kinases phosphorylation The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly by increased ... regulation of ethanol- induced apoptosis in HepG2 cells exposed to low concentrations of ethanol The findings of the present study provide new evidence that ethanol at low...

Ngày tải lên: 31/10/2012, 15:37

... et al 18 Ohno-Iwashita Y, Shimada Y, Waheed AA, Hayashi M, Inomata M, Nakamura M, Maruya M & Iwashita S (2004) Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts Anaerobe ... separation of the plasma membrane depending on cholesterol content might be involved in segregating signalling molecules from each other to maintain the ‘off’ state of T-cell si...

Ngày tải lên: 20/02/2014, 03:20

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786...

Ngày tải lên: 07/03/2014, 16:20

... on KS1 and q is displayed in Fig 4, showing that two regions can be defined in the space of kinetic parameters (q, KS1), one resulting in bistable behavior and the other resulting in a single stable ... provided that some individual signaling elements are doubly modified proteins and the enzymes catalyzing these modifications follow a particular set of kinetic requirements Th...

Ngày tải lên: 16/03/2014, 13:20

... FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur J Biochem 269) 1051 Fig Scheme of the major insulin signaling pathways The activated insulin receptor phosphorylates tyrosine residues ... FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur J Biochem 269) 1059 89 Dadke, S., Kusari, J & Chernoff, J (2000) Down-regulation of insulin s...

Ngày tải lên: 17/03/2014, 23:20

... explained by the single AhR pathway The molecular mechanism involved in the AhR-independent pathway( s) leading to TCDDinduced immunotoxicity is not clearly understood, and indeed the lack of a ... PKCh and specifically sup906 press its kinase activity To confirm that PKCh kinase activity really does participate in the signal transduction mechanism invo...

Ngày tải lên: 23/03/2014, 13:20

... activation via distinct signal transduction events would converge on the as-1-like element in the tobacco PR-1a promoter (Fig 7) Our model is consistent with the existence of small protein families of ... (2000) Tobacco transcription factor TGA2.2 is the main component of as-1binding factor ASF-1 and is involved in salicylic acid- and auxininduci...

Ngày tải lên: 23/03/2014, 15:21

... applied and (c) assume a similar role by putative endogenous ouabain or OLF Ouabain- sensitive and -insensitive a- isoforms of Na+/K+-ATPase in rats All isoforms of the catalytic a- peptide of Na+/K+-ATPase ... rat by another group in collaboration with Hamlyn [21] by means of two independent assays, a radioimmunoassay using an anti -ouabain Ig and an enzymat...

Ngày tải lên: 23/03/2014, 17:21

... actin cortex under the membrane of blebs in filamin-deficient blebbing cells has not been examined in blebs of cells undergoing cell death Although the proteins involved in the execution of blebbing ... tropomyosin and the actin-bundling protein, a-actinin Finally, myosin is recruited and is concentrated in a few distinct dots along the cortex [4] When examined by scanning...

Ngày tải lên: 29/03/2014, 08:20