protein adducts at critical protein sites as markers of toxicological risk

... similar to that in Asp141 of Met8P. The idea of NirF being a dehydrogenase is appealing because of the presence of a putative nucleotide-bind- ing motif in the N-terminal of the protein sequence and ... to seek accu- mulation of the substrate of NirF in a mutant that lacks NirF; this too is not trivial as the DnirF strain does not accumulate readily...

Ngày tải lên: 15/02/2014, 01:20

... examined the role of residues in the C-terminal extensions of other sHsps, notably aA- and aB-crystallin, the flexible regions of these proteins are unique and distinct from that of Hsp25. The ... residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity Amie M. Morris...

Ngày tải lên: 07/03/2014, 04:20

... localization of MPP3, a novel member of the MPP5 protein scaffold at the outer limiting membrane (OLM), and of the DLG1 protein scaffold at the outer plexiform layer of the retina. MPP3 localized at ... photoreceptors and Mu ă ller glia cells. Based on the recruitment of MPP3 to the MPP5 protein scaffold at the OLM, the involvement of...

Ngày tải lên: 16/03/2014, 13:20

... GAGAATCAGTGTCGACTTCATCTATAAAAATAATAGAAGGTTTATT Vps4 SalIF GCCCATATTCGTCGACGCGCTAACAGGTACCAGAGGAGAAGGAGAGAGCGAAGCAAGTAG Vps4 Dstr R GGGCGGATCCTCTGCTTTTCTTTATC YEE F CTGGACACAGCCACGCAGTATACAGCATACTATAACGG YEE R CCGTTATAGTATGCTGTATACTGCGTGGCTGTGTCCAG IRA ... Vta1p and Vps46 p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl...

Ngày tải lên: 23/03/2014, 09:20

... 2005 FEBS 57 61 End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair Jason L. Parsons 1 , Irina I. ... strand break, verication of the nature of the 3Â end, and identification of a satis- factory pathway for repair. The XRCC1 component of th...

Ngày tải lên: 23/03/2014, 11:20

... the value of the variables result in different PD estimations.

Ngày tải lên: 29/03/2014, 08:20

... because, at the end of the experiment, the function of the target protein is likely still to be unknown. However, the analysis of the submitted predictions made the assessors conclude that [13]: (a) ... of the 3D protein structure. Therefore, the set that was considered contained 64 protein targets, 29 of which had no functional annotation in any data- ba...

Ngày tải lên: 30/03/2014, 10:20

... important for phosphorylation at Ser9 and Thr18. These results also suggest that the conformation change induced by the binding of p53 to ssDNA and DNA ends facilitates the presentation of Ser9 and T hr18 ... of p53 Wt or p53 S9A/T18V phosphorylation by DNA- PK . DNA- PK was incubated with the indicated p53 species in the presence of 50 l M ATP and assess...

Ngày tải lên: 30/03/2014, 15:20

... All rights reserved Research Paper Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema Pedro J Modrego 1 , Beatriz Boned 2 , ... markers of brain edema in stroke at baseline and after 48 hours respectively. Given that brain edema may be a life-threatening condition, anti-edem...

Ngày tải lên: 08/08/2014, 16:23

... Tomiyama H, Ichihashi H, Nagae T, Tanaka N, Takazawa K, Ishimaru S, Yamashina A: Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery ... function in a community-dwelling population Norio Sugawara* 1 , Norio Yasui-Furukori 2 , Takashi Umeda 3 , Ayako Kaneda 2 , Yasushi Sato 1 , Ippei Takahashi 3 ,...

Ngày tải lên: 11/08/2014, 16:22

... progressively affected, influencing intrapulmonary gas mixing and gas exchange. We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence ... Polkey MI, Lofaso F: Setting of noninvasive pressure support in young patients with cystic fibrosis. Eur Respir J 2004, 24:624-630. 31. Fauroux B: Nonivasive...

Ngày tải lên: 12/08/2014, 14:20

... CTACCAAGCC TCC, 696 +A, GGCTTGGTAGGTTTAGCTAGAA- TAGTTTTTGCT/AGCAAAAACTATTCTAGCTAAAC CTACCAAGCC,695+ 2A, GAGGCTTGGTAGGTGCTG CCTTAAGAATAGTTTTTGC/GCAAAAACTATTCT- TAAGGCAGCACCTACCAAGCCTC,695+ 3A, GTAG GAGGCTTGGTAGGTGCGGCCGCATTAAGAATAG- TTTTTGCTGTACGTACAGCAAAAACTATT ... GTAG GAGGCTTGGTAGGTGCGGCCGCATTAAGAATAG- TTTTTGCTGTACGTACAGCAAAAACTATT CTTA- AT GCGGCCGCACCTACCAAGCCTCCTAC, 695+ 4A, GGAGGCTTGGTA...

Ngày tải lên: 13/08/2014, 01:20

... was able to detect plasma cytokines in 710 (69.6%) assays. (Here we define 'assay' as each cytokine measured, which was performed on each individual plasma sample.) Concentrations of ... multiplex analysis of plasma cytokines in patients with severe sepsis and septic shock was able to iden- tify cytokine profiles associated with early and late mortality, as well...

Ngày tải lên: 13/08/2014, 03:21

... RESEARCH Open Access Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary ... and VIIIa [1]. Inactivation of factor VIIIa reduces the acti vity of the tenase complex and the production of factor Xa. Inactivation o...

Ngày tải lên: 14/08/2014, 07:21

... given Protein Adducts at Critical Protein Sites as Markers of Toxicological Risk Presented by Paul Getty to The University of Glasgow for the degree of Doctor of Philosophy ... Glasgow Theses Service http://theses.gla.ac.uk/ theses@gla.ac.uk Getty, Paul (2014) Protein adducts at critical protein sites as markers of...

Ngày tải lên: 22/12/2014, 21:29