... 4279 Thioredoxin reductase from the malaria mosquito Anopheles gambiae Comparisons with the orthologous enzymes of Plasmodium falciparum and the human host Holger Bauer1, Stephan Gromer1, Andrea ... AAG25639),humans (hTrxR, AAB35418), and from the malaria parasite Plasmodium falciparum (PfTrxR-1, CAA60574). The enzyme of Anopheles shares69%, 52%, and 45% sequence identity with the TrxRs of D. ... characterization of A. gambiae TrxR allows the comparison of three differentmechanisms of Trx reduction in the P. falciparum malaria system, i.e. that in the parasite, the human host, and the insect...