targeting cancer cell metabolism as a therapeutic strategy

... the words of Ramanathan, we read that: Creative economy : as a development strategy : a view of developing countires / editor Ana Carla Fonseca Reis. – São Paulo : Itaú Cultural, 2008. ... São Paulo 2008 Ana Carla Fonseca Reis editor CREATIVE ECONOMY as a development strategy: a view of developing countries GLOBAL VIEWS 50

Ngày tải lên: 14/02/2014, 08:20

... effect. Only on closer examination of the full metabolic requirements of a cancer cell was the advantage of PKM2 expression revealed. A cancer cell, like any normal cell, must obtain the building ... capacity of antioxidant systems to eliminate ROS and RNS. Regulation of cancer cell metabolism Rob A. Cairns*, Isaac S. Harris* and Tak W. Mak Abstract | Interest...

Ngày tải lên: 15/02/2014, 04:20

... \allow repetition and re-evaluation of cases. Reliability is most important during the data collection phase, and involves the use of case study protocol as well as the case study database already ... important if other researchers are to be able to repeat a research programme: It is for this reason that researchers like Yin are especially adamant that a case d...

Ngày tải lên: 20/02/2014, 11:20

... lung cancer that s/he has a 50% 5-year survival rate. In general, today’s cancer survival rates and median survival times are estimated from a large group of cancer patients; while these estimates ... Baracos Department of Oncology University of Alberta Edmonton, AB T6G 1Z2 vickie.baracos@ualberta.ca Abstract An accurate model of patient survival time can help in the...

Ngày tải lên: 06/03/2014, 02:21

... MINIREVIEW The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease Peter J. Crouch 1 , Anthony R. White 1 and Ashley I. Bush 2,3 1 Department of Pathology ... bio-availability have the potential to ameliorate several of the dysfunctional events characteristic of Alzheimer’s disease. Metal- based...

Ngày tải lên: 07/03/2014, 10:20

... FEBS Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation Marta Sousa Silva 1 , Anto ´ nio E. N. Ferreira 1 , Ana ... evaluating the relevance of the glyoxalase pathway as a potential therapeutic target by revealing the importance of critical parameters...

Ngày tải lên: 23/03/2014, 13:20

... Miranda E, Ro ă misch K & Lomas DA (2004) Mutants of neuroserpin that cause dementia accumulate as poly- A therapeutic strategy for the serpinopathies L. K. Sharp et al. 2550 FEBS Journal ... (2002) Serpinopathies and the conformational dementias. Nat Rev Genet 3, 759– 768. 35 Lomas DA & Mahadeva R (2002) a 1 -Antitrypsin poly- merization and the serpino...

Ngày tải lên: 30/03/2014, 11:20

... 32:468-478. doi:10.1186/1479-5876-8-113 Cite this article as: d’Hennezel et al.: IL-2 as a therapeutic target for the restoration of Foxp3 + regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and ... for several years to facilitate hematopoietic stem cell trans- plantation (HSCT). Studies in such patients i...

Ngày tải lên: 18/06/2014, 16:20

... hematological < /b> cancer < /b> cell < /b> lines < /b> is < /b> a < /b> Negative < /b> Predictor < /b> of < /b> Response < /b> to < /b> the < /b> inhibition < /b> of < /b> Aurora < /b> B and C by GSK1070916 Christopher Moy * , Catherine A < /b> Oleykowski, Ramona Plant, Joel Greshock, ... Junping Jing, Kurtis Bachman, Mary Ann Hardwicke, Richard Wooster and Yan Dege...

Ngày tải lên: 18/06/2014, 22:20

... 9-16. doi:10.1186/1479-5876-9-110 Cite this article as: Moy et al.: High < /b> Chromosome < /b> Number < /b> in < /b> hematological < /b> cancer < /b> cell < /b> lines < /b> is < /b> a < /b> Negative < /b> Predictor < /b> of < /b> Response < /b> to < /b> the < /b> inhibition < /b> of < /b> Aurora < /b> B and C by GSK1070916. Journal of < /b> ... polyploidy pheno- t...

Ngày tải lên: 20/06/2014, 04:20

... signaling via CD20 Commentary B cells as a therapeutic target in autoimmune disease Jörg J Goronzy and Cornelia M Weyand Departments of Medicine and Immunology, Mayo Clinic, Rochester, MN, USA Corresponding ... diseases. Preliminary clinical studies suggest therapeutic benefits in patients with classic autoantibody-mediated syndromes, such as autoimmune cytopenias. Treat...

Ngày tải lên: 09/08/2014, 01:21

... O'Reilly LA, Kuida K, Strasser A: Transforming growth factor beta-dependent sequential acti- vaiton of Smad, Bim, and caspase-9 mediates physiological approaches in gastric epithelial cells. ... mitochondrial membrane potential, may have increased levels of cell surface MHC, are easily damaged by free radicals (including excessive reactive oxygen intermediates), and may show increased...

Ngày tải lên: 11/08/2014, 10:23

... http://respiratory-research.com/content/2/2/080 Introduction Asthma is a complex heritable inflammatory disorder of the airways associated with airway obstruction as well as a variety of clinical signs [1,2]. Airway hyperresponsiveness (AHR), a risk factor ... risk factor and a cardinal feature of asthma, is characterized as an exaggerated airway response to an irri- tant s...

Ngày tải lên: 12/08/2014, 18:20

... eukaryotic translation initiation factor 4E-binding protein 1 ACL, ATP citrate lyase ACN, aconitase ADP, adenosine diphosphate ALD, aldolase ALT, alanine transaminase AKT, protein kinase ... diphosphate ; ALD, aldolase ; ALT, alanine aminotransferase; ATP, adenosine triphosphate; CS, citrate synthase; ENO, enolase; FA, fatty acids; FAD, flavin adenine dinucleotide; FASN, fatty acid .....

Ngày tải lên: 22/12/2014, 20:36