clinical and epigenetic factors underlying treatment refractory rheumatoid arthritis

... to destroy intracellular micro-organisms and tumour cells. Therefore, recombinant IFN-γ has been used clinically for the treatment of a variety of conditions, including chronic lymphocytic leukaemia, ... enhancement of T-cell cytotoxity; regulation of antibody production; inhibition of T-cell prolif- eration and migration; enhancement of IL-2 production by Th1 cells; upregulat...

Ngày tải lên: 09/08/2014, 01:21

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... for myeloid cell-mediated inflammation and bactericidal capacity of phagocytes, suggesting crosstalk between angiogenesis and inflammation. Review Hypoxia The role...

Ngày tải lên: 09/08/2014, 01:22

... production of TNF-α and IL-10 by monocytes. Spontaneous production of IL-10 and TNF-α by monocytes could not be detected; cytokine production was induced, however, by addition of LPS (control samples). ... dibutyryl cAMP, forskolin, and VIP were tested for cytotoxicity and displayed no toxi- city at the concentrations being used in this study as determined by (3-[...

Ngày tải lên: 09/08/2014, 01:23

... these molecules in normal homeostasis. Review Chemokine blockade: a new era in the treatment of rheumatoid arthritis? Jasper J Haringman and Paul P Tak Division of Clinical Immunology and Rheumatology, Academic ... migration selectively [20]. In that study a highly specific neutralizing antibody against IL-8 was administered in several types of acute inflammato...

Ngày tải lên: 09/08/2014, 01:23

... movement Yes Yes s810 Structure of areas of skin Yes Yes s830 Structure of nails Yes International Classification of Functioning, Disability and Health (ICF) categories of the ICF Core Set for rheumatoid ... the skin Yes b850 Functions of hair Yes b860 Functions of nails Yes International Classification of Functioning, Disability and Heal...

Ngày tải lên: 09/08/2014, 08:22

... potent inhibitor for the synthesis of proin- flammatory cytokines in monocytes /macrophages and T cells [11], is substantially expressed by lining macrophages and infiltrating T cells in the inflamed ... 4 Induction of mRNA expression of type 1 and type 2 tumour necrosis factor receptor (TNFR1/2) in monocytes by interleukin-10 (IL-10)Induction of mRNA expres...

Ngày tải lên: 09/08/2014, 08:22

... cited. Research Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and ... asso- ciated with severe acute radiation pneumonitis in patients with locally advanced non-small cell l...

Ngày tải lên: 09/08/2014, 08:23

... potential application in treatment of rheumatoid arthritis Dong Wang 1,2 , Scott C Miller 3 , Xin-Ming Liu 1 , Brian Anderson 3 , Xu Sherry Wang 1,4 and Steven R Goldring 5,6 1 Department of Pharmaceutical ... diagnosis and treatment of RA. Although progress has been made in understanding the molecular mechanisms and identification of novel therapeutic target...

Ngày tải lên: 09/08/2014, 10:20

... amyloid and advanced glycation end products (AGEs) [15]. AGEs are the products of nonenzymatic glycation and oxidation of proteins that form with aging, diabetes and renal failure, and at sites of inflammation ... Goodson and colleagues recently demonstrated 10% mortality, predominantly owing to CV events, within 10 years of onset of inflammatory polyarthri- t...

Ngày tải lên: 09/08/2014, 10:20

... Inoue E, Toyama Y, Hara M, Yamanaka H, Tomatsu T, Momohara S, Kamatani N: Failure to confirm associ- ation between PDCD1 polymorphisms and rheumatoid arthri- tis in a Japanese population. J Hum Genet ... with rheumatoid arthritis in the European Caucasian population: a family-based study. Arthritis Res Ther 2007, 9:R63. 2. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM,...

Ngày tải lên: 09/08/2014, 10:21

... 5 Research article Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: ... immunoablative therapy of ACPA-IgG autoantibodies with low avidityRegeneration after immunoablative therapy of ACPA-IgG autoantibodies with...

Ngày tải lên: 09/08/2014, 10:21

... cigarette smoking associates with reduced BMI and BF in patients with RA and heavy smoking associates with lower muscle mass. Smoking cessation appears to associate with increased BMI, BF, and waist ... identify potential associations of smoking with body weight and composition of RA patients. Methods A total of 392 patients (290 females)...

Ngày tải lên: 09/08/2014, 10:23

... peripheral blood and bone marrow. Rituximab preferentially depletes B cells in peripheral blood (PB) and reduces < /b> activated < /b> B cells in the PB and the bone marrow (BM) of rheumatoid arthritis (RA) patients. ... patients. Favorable response to rituximab therapy < /b> preceded by a decrease in CD19 + CD27 + memory B cells in...

Ngày tải lên: 09/08/2014, 14:22

... the original work is properly cited. Research article Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment Lisa ... disease during IFN /β treatment and circulating IFN inducers [2,3]. Type I IFN activity in SLE is associated with disease severity [...

Ngày tải lên: 12/08/2014, 11:22

... baseline and six months in biologic resistant group 132! Table 3-42 Disability (HAQ) at baseline and six months 133! Table 3-43 Bivariate analysis of disability (HAQ) and clinical and biochemical ... components and HADS- D/HADS-A scores 136! Table 3-45 FACIT fatigue results at baseline and six month study visits 137! Table 3-46 Correlation between fatigue and clinical, bioch...

Ngày tải lên: 22/12/2014, 19:13