... forms the mature capsid of the human immunodeficiency virus. Capsid assembly involves hexamerization of the N-terminal domain and dimerization of the C-terminal domain of CA (CAC), and both domains ... [1]. The structural retroviral polyprotein (Gag) of HIV-1 forms the immature capsid, and is subse-quently cleaved by the viral protease into severalmature proteins: the matrix, the capsid protein ... carboxyl-terminaldimerization domain of the HIV-1 capsid protein. Science 278, 849–853.23 Worthylake DK, Wang H, Yoo S, Sundquist WI & HillCP (1999) Structures of the HIV-1 capsid protein dimerization domain...