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ROLE OF RAP1 IN ANGIOGENESIS AND TUMOR INVASION

ROLE OF RAP1 IN ANGIOGENESIS AND TUMOR INVASION

ROLE OF RAP1 IN ANGIOGENESIS AND TUMOR INVASION

... suggest that Rap1, although not as strong an oncogene as Ras, plays an important role in the tumorigenic process. 3.2. Rap1 and tumor invasion and metastasis The role of Rap1 in tumor metastasis, ... dissection of the precise roles of Rap1 in different cancer types. 3.3. Rap1 and brain tumors 3.3.1. Brain tumor overview Although brain tumors represent only approximately 2% of all cancers, ... regulation of CDC24 in yeast. Overexpression of Vav2 and Tiam1 activates Rac independently of Rap1, but in order to promote cell spreading, the redistribution of Vav2 and Tiam1 to the cell edge by Rap1...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx

Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx

... culled. No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008). Regarding the ... their role in poultry rearing, women should also be encouraged to be actively involved in training programs and in dissemination of information regarding biosecurity technologies. Finally, ... (in agriculture, mining, manufacturing, services, and so on), income from livestock and crop sales, and remittances, rent income, and other reported income. On average, poultry (live bird) and...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx

Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx

... Replacement of terminal cys-teine with histidine in the metallothionein a and bdomain maintains its binding capacity. Eur J Biochem259, 519–527.R. Bofill et al. C. elegans CeMT1 and CeMT2 metallothioneinsFEBS ... P17512). The coordinat-ing and putative coordinating residues are highlighted (Cys in grey shadow, His and Tyr in bold) and the total content in each peptide is indicated. The initial GS residues ... bonds. In vivo and in vitro Cd(II)-binding abilities of CeMT1 and CeMT2Unlike the results obtained for Zn(II) coordination,the biosynthesis in Cd-supplemented cultures of thetwo wild-type CeMT1 and...
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Báo cáo khoa học: Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagicEscherichia coli: role of EspL2 in adherence and an alternative pathway for modulating cytoskeleton through Annexin A2 function pot

Báo cáo khoa học: Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagicEscherichia coli: role of EspL2 in adherence and an alternative pathway for modulating cytoskeleton through Annexin A2 function pot

... The interaction of EspL2 with Annexin A2increases F-actin bundling activity and strengthens the membrane–cytoskel-eton linkage, resulting in the condensation of actin fibers and the induction of ... (T3SS) and modulates cellular func-tion [2]. Injected Tir is localized in the host-cellmembrane and forms a receptor for intimin. Binding of intimin to the extracellular domain of Tir induces ... An in vitro assay for the actin bundling activity of Annex- in A2 clearly indicated enhancement of Annexin A2activity in the presence of EspL2 protein [8]. Further-more, depletion of Annexin...
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aging of the genome the dual role of dna in life and death mar 2007

aging of the genome the dual role of dna in life and death mar 2007

... Nevertheless, explaining aging in terms of one universal, driving force is not entirely unrealistic in view of the universality of the principles behind the living world on this planet. In spite of its bewildering ... way of interrupting the pathway of mutationaccumulation increasing the chance of sexual reproduction to produce high-fitness off-spring. In this case, senescence has been explained as offering ... has been so successful in the past in providing insights into the molecularmachinery of many living systems and will continue to do so in further unraveling genefunction in functional genomics...
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báo cáo hóa học:

báo cáo hóa học:" Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer" pdf

... expression of miR-181a,miR-181b, and miR-213 in OVCA cell lines results in resistance to doxorubicin and gemcitabine and increasedexpression of miR-99b and miR-14 leads to docetaxel and paclitaxel ... overexpression of miR-375 resulted in sup-pressed glucose-stimulated insulin secretion and its inhi-bition resulted in enhanced insulin secretion.Myotrophin, a protein that has a role in exocytosis, ... targeting dereg-ulated miRNAs will be the future tool for cancertreatment. Using data from miRNA profiling and knowl-edge of familial history of a certain diseases will help in developing miRNA-based...
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AUTISM SPECTRUM DISORDERS: THE ROLE OF GENETICS IN DIAGNOSIS AND TREATMENT pot

AUTISM SPECTRUM DISORDERS: THE ROLE OF GENETICS IN DIAGNOSIS AND TREATMENT pot

... that code for proteins from the family of neurexins and neuroligins that play, in turn, a role in the development and functioning of synaptic and in particular glutamatergic and GABA-ergic networks ... El-Husseini, 2006; Buchsbaum, 2009). The first X-linked mutations in genes involved in the coding of neuroligin were revealed in patients with autism in two Swedish families in 2003 (Jamin et ... groups. The findings of this study reveal that the PDD-NOS group had a high number of features in common with the autism and the ADHD groups, in terms of presenting and/ or reported symptoms and developmental...
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Báo cáo y học:

Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc

... report increased levels of leptin during infectious and inflammatory processes. Leptin expression in adiposetissue and circulating leptin levels are increased afteradministration of inflammatory ... leptin, adiponectin and resistin, as well ascytokines and chemokines. Altered levels of different adipo-cytokines have been observed in a variety of inflammatoryconditions (reviewed in [27]) and, ... (reviewed in [27]) and, in particular, the role of leptin in immune responses and inflammation has latelybecome increasingly evident. Altered leptin production duringinfection and inflammation strongly...
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 Circuit theory of finance and the role of incentives in financial sector reform

Circuit theory of finance and the role of incentives in financial sector reform

... capitalprofitability is declining. The internalization of information within the same institution may thusenhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing.The ... placing money withinvestment financial institutions in the capital market, and hold the remaining share in non-interest bearing, short-term bank deposits (eq. 7). The share of savings going ... leading to overfinancing of capital good production. Figure 1 shows financialinvestors rationing investing companies at the point of maximum risk-adjusted gross rate of return, *−Lr , and...
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