PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYMES REGULATE DEATH ASSOCIATED PROTEIN KINASE (DAPK) IN CERAMIDE-INDUCED ANOIKIS

... E. Death Associated Protein Kinase (DAPK)- Structure and Function Death- associated protein kinase (DAPK) is a calcium/calmodulin (Ca 2+ /CaM)-dependent serine/threonine kinase that regulates ... microtubule associated protein 1B (MAP1B) to regulate autophagy (43). The calmodulin binding domain interacts with Ca 2+ /CaM to regulate the kinase activity...

Ngày tải lên: 24/08/2014, 13:27

... (DAPK-1) is a Ca 2+ ⁄ calmodulin-regulated serine ⁄ threonine kinase composed of multiple functional domains, including a kinase domain, a calmodulin-binding domain, eight ankyrin repeats, two P-loop ... mitogen-activated protein kinase kinase (MEK) ⁄ ERK signaling pathway [3]. Moreover, a germline mutation in the death domain of DAPK-1 has been found to reduce intrinsic oligomeri...

Ngày tải lên: 18/02/2014, 17:20

... (2000) WD40 repeat proteins striatin and S ⁄ G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that asso- ciate with protein phosphatase 2A. J Biol Chem 275, 5257–5263. 15 ... Rivers AM, Audlin S & Virshup DM (1996) The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation- induced phosphoproteins that ta...

Ngày tải lên: 06/03/2014, 02:20

... (2001) Protein phosphatase 2A: a highly regulated family of serine /threonin e phosphatase s implicated in cell growth and signalling. Biochem. J. 353, 417±439. 2. Virshup, D.M. (2000) Protein phosphatase ... (2000) WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phos- phatase...

Ngày tải lên: 08/03/2014, 10:20

... of an N-terminal kinase domain, a calmodulin-binding domain, eight ankyrin repeats, two nucleotide binding domains (P-loops), a cytoskeleton binding domain and a C-terminal death domain. A mutant ... control interferon responses. EMBO J 29, 1748–1761. 19 Widau RC, Jin Y, Dixon SA, Wadzinski BE & Gallagher PJ (2010) Protein phosphatase 2A (PP2A) holoenzymes regulate deat...

Ngày tải lên: 28/03/2014, 23:20

Ngày tải lên: 29/03/2014, 08:20

... September 2009) doi:10.1111/j.1742-4658.2009.07411.x Death- associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain ... signalling pathways. Table 1. DAPK binding proteins, the region of DAPK important for mediating the protein- protein interactio...

Ngày tải lên: 29/03/2014, 08:20

... 2009) doi:10.1111/j.1742-4658.2009.07412.x Death- associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning ... dissect this fascinating process. Abbreviations DAPK, death- associated protein kinase; ERM, ezrin ⁄ radixin ⁄ moesin; MAP1B, microtu...

Ngày tải lên: 29/03/2014, 08:20

... role of death- associated protein kinase (DAPK) in the regulation of autophagy is particularly interesting. DAPK is a serine ⁄ threonine kinase originally isolated by a genetic screening for positive ... lymphoma; DAPK, death- associated protein kinase; FoxO, forkhead transcription factor; JNK, c-Jun N-terminal kinase; MAP, microtubule -associated protein; mTOR, mammal...

Ngày tải lên: 29/03/2014, 08:20

... Sciences, Faculty of Medicine, University of Glasgow, UK Introduction Death- associated protein kinase (DAPK) is a cal- cium ⁄ calmodulin-regulated serine ⁄ threonine protein kinase, located on chromosome ... 2009) doi:10.1111/j.1742-4658.2009.07414.x Death- associated protein kinase (DAPK) is a pro-apoptotic serine ⁄ threo- nine protein kinase that is dysregulate...

Ngày tải lên: 29/03/2014, 08:20