FUNCTIONAL INSIGHTS INTO ONCOGENIC PROTEIN TYROSINE PHOSPHATASES BY MASS SPECTROMETRY

... represent hyperactive mutants of protein tyrosine kinases found in the genome and thus distort the delicate phospho- tyrosine balance within cells. Protein tyrosine phospha- tases (PTPs), by virtue of their ... (2008) Pro- tein tyrosine phosphatases: regulatory mechanisms. FEBS J 275, 831–847. 2 Pulido R & Hooft van Huijsduijnen R (2008) Protein tyrosine phosphatases:...

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... remains to be determined. Ó FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur. J. Biochem. 269) 1055 MINIREVIEW Coordinated action of protein tyrosine phosphatases in insulin signal ... deactivation of insulin receptor substrate-1 by protein- tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with th e Grb2 adaptor protein....

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... motif; LMW-PTP, low molecular weight protein tyrosine phosphatase; N-SH2, N-terminal SH2 domain; PTP, protein tyrosine phosphatase; RPTP, receptor protein tyrosine phosphatase; YopH, Yersinia ... human protein tyrosine phosphatase 1B. Science 263, 1397–1404. 7 Jia Z, Barford D, Flint AJ & Tonks NK (1995) Struc- tural basis for phosphotyrosine peptide recognition by prot...

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... A ˚ 2 ) found in protein protein complexes [26]. The shape comple- mentarity S c [27] of the two tetramers is 0.517, which corresponds to the lower limit of S c found in protein protein interfaces. ... growth. The hydrophobic inter- actions were not taken into consideration, although they are very important in evaluating the stability of protein protein complexes. However, the calcul...

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... erythroleukemogenesis by inhibit- BioMed Central Page 1 of 11 (page number not for citation purposes) Retrovirology Open Access Review Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic ... induces receptor dimerization followed by the activation of the intrinsic tyrosine kinase and receptor transphosphoryla- tion on specific tyrosine residues [111,112]...

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... polymorphism of apolipoprotein C1 FEBS Journal 273 (2006) 4707–4715 ª 2006 The Authors Journal compilation ª 2006 FEBS 4711 A functional polymorphism of apolipoprotein C1 detected by mass spectrometry Matthew ... of ApoC1 as well as some protein properties that suggest the functional significance of this residue change. They Keywords apolipoprotein C1; mass spectrometry; polymo...

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... Resonance Mass Spectrometry VCH, Wemheim, Germany 15 Busch, K. L., Glish, G. L., and McLuckey, S. A. (1988) Mass Spectrometry /Mass Spectrometry Technzques and Applications of Tandem Mass Spectrometry ... Combined liquid chromatography mass spectrometry Part II Techniques and mechanisms of thermospray Mass Spectrom Rev 9,63 l&669 9 Dawson, P H (1976) Quadrupole Ma...

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... stereospecificity at C5 of coenzyme F 420 for F 420 H 2 oxidase from methanogenic Archaea as determined by mass spectrometry Henning Seedorf 1 ,Jo ¨ rg Kahnt 1 , Antonio J. Pierik 2 and Rudolf K. Thauer 1 1 ... spectra (white). For better visibility in the structures deuterium is abbreviated by D rather than by 2 H and hydrogen by H rather than 1 H. Mtd, Si-face- specific F 420 -dep...

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... time-of-flight mass spectrometer (Micromass LC-T; Waters, Manchester, UK) modified for high mass operation and operating in positive ion mode [32]. To monitor RNA cleavage by Kid protein a robotic ... methods). Protein syn- thesis was inhibited by the wild-type Kid protein, the KidT69G mutant and to a lesser extent by KidA55G (Fig. 4). The double mutant KidA55G ⁄ T69G was also ab...

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