Báo cáo y học: "Malaria genomics meets drug-resistance phenotyping in the field" pps

... sulfadoxine/pyrimetha- mine showed discontinuities in the phenotype distribution, presumably reflecting the effect of one dominant mutation, whereas other drugs such as quinine and dihydro- artemisinin ... selection or whether they represent the appearance of new resistance variants? Volkman demonstrated the versatility of high-density, genome-wide genotyping arrays in determi...

Ngày tải lên: 14/08/2014, 21:21

Ngày tải lên: 14/08/2014, 07:21

... reactivity than the control line. Of these genes, four have been previously implicated to affect activity: muscle- blind mutants are paralytic [36]; Amphiphysin [37] and Cysteine string protein [38] ... of the co-isogenic control line (B) in each block. We used the following ANOVA model to determine whether the locomotor reactivity of the mutant lines differed significantly from...

Ngày tải lên: 14/08/2014, 08:20

... in any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity. In this case, although the patient ... are not seen as frequently as they have been in the past due to better con- trol of the disease. Competing interests The author(s) declare that they have no competing inter-...

Ngày tải lên: 25/10/2012, 10:06

... and consequently the EDTA-IM. Hydroxyproline, hydroxy- lysine and phosphoserine were not detected in WSM, WIM, EDTA-SM and EDTA-IM. The comparison of the amino acid composition of the main peak obtained ... revealed the predominance of two amino acids: alanine (39.2%) and glycine (30%). Interestingly, the proportions are very similar to those found in WSM for alanine and glyci...

Ngày tải lên: 21/02/2014, 01:21

... agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G-protein coupling of the 7TM)7TM moiety is mediated by another ... 2002 Agonist-induced rearrangement of the 7TMs in the CaR homodimer? One of the goals of the present study was to investigate, whether the activating twist in the ATD...

Ngày tải lên: 08/03/2014, 09:20

... that of his- tamine or methacholine, which indicates that these mediators are extremely potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cysteinyl leukotriene receptors ... arachidonic acid, thereby preventing cysteinyl leukotriene synthe- sis (see Figure 1). Blocking arachidonic enzy- matic conversion by the use of 5-lipoxygenase inhibitors does protect aga...

Ngày tải lên: 08/08/2014, 20:23

... 1993;92:644–51. 24. Durham SR, Ying S, Varney VA, et al. Grass pollen immunother- apy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells ... memory IgE production. 1,6 On the other hand, IL-10 induced by specific immunotherapy suppresses IgE and synthesizes IgG4. In vitro studies demonstrate nonana- phyl...

Ngày tải lên: 08/08/2014, 21:20

... (dehydro- genation, hydroxylation, and N-dealkylation), mainly by cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only a minor effect ... (7-(4-[4-(2,3-dichlorophenyl)-1-piperazi- nyl]butyloxy)-3,4-dihydro-2 (1H)-quinolinone (OPC- 14597), is a derivative of the dopamine autoreceptor ago- nist 7-(3-[4-(2,3-dimet...

Ngày tải lên: 08/08/2014, 23:21

... non-inflammatory conditions [2]. Most chemokines play a role in inflammatory conditions by inducing integrin activation, chemotaxis, and angiogenesis. Apart from modulating migration directly, ... on the available in vivo data, which may provide more insight into the chances that disrupting one single factor of the complicated chemokine network could be clinically effective in chr...

Ngày tải lên: 09/08/2014, 01:23