... sequences of the naturally occurring cyclic MccJ25anditslinearvariants.MccJ25-L1)21is the thermolysin-linearizedMccJ25, previously named MccJ25-L in [19]. MccJ25-L12)11displays the sequence of the ... crabpincer-like regions described in the MccJ25 structure [20] arenot maintained in the linear form. Thermolysin cleaves the Phe21–Val1 bond, thus the loss of the bigger crab-pincer,which includes ... mammaliandefensins [2,3], but also the cyclic bacteriocin AS48,cyclotides, rhesus theta-defensin-1 (RTD-1) and syntheticlinear analogues [35–38], all exhibit MICs in the range of 0.5–20 lM.Thermolysin...