Báo cáo y học: "Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies" docx

... aim of the study to extend the limits of the detections. Future improvements in the accuracy and cover-age of annotations are likely to improve also the reliability of the exon array results. The ... isapplicable to any existing or future annotation scheme. In addition to the annotation accuracy, another challengingissue in the detection of differential splicing is the complexity of the splicing process. ... expression intensities are first sum-marized into an exon- level intensity and the correspond-ing gene-level intensity . The exon intensity is thennormalized by the gene intensity, producing the normalizedintensity...

Báo cáo y học: "Acquired hemophilia as the cause of lifethreatening hemorrhage in a 94-year-old man: a case report" pot

... every 6 to 8 hours) or by continu-ous infusion (3 to 4 IU/kg/hour) [2]. The Bethesda assaywas not immediately available in our case and the lack of another bypass agent in the setting of severe ... adjusteddepending on plasma FVIII levels and bleeding symp-toms [2]. Another interesting finding in our case was the p resence of persistent melena for two weeks in the setting of persistent bleeding ... thromboplas-tin time without other cause.ConsentWritten informed consent was obtained from the patient’s next of kin for publication of this case reportand any accompanying images. A copy of the writtenconsent...

Báo cáo y học: "Acquired hemophilia as the cause of lifethreatening hemorrhage in a 94-year-old man: a case report" potx

... use in acquiredhemophilia in the US [2]. By directly activating FX on the surface of activated platelets at the site of injury(thereby bypassing FVIII and FIX), rFVIIa can circum-vent the ... extensively in congenitalhemophilia [4], we describe only the sixth cas e of use of aminocaproic acid in a setting of acquired hemophilia[4-8]. We found only one other case in the literature of severe ... bradycardia that developed in the setting of severe bleeding from acquired factor VIII inhibitor, but the authors did not address whether this bradycardiawas associated with the infusion of aminocaproic...

Báo cáo y học: " New approaches to the modulation of inflammatory processes in airway disease models" pdf

... delivereddirectly into the airways, can be transformed by esterasecleavage into the active metabolite (R-M1) producing highlocal anti-inflammatory activity. The anti-inflammatory effi-cacy of Ciclesonide ... increased the secretion of serous mucus in mousetrachea as well as reducing LPS-induced neutrophilia in rats and pigs.Kinase inhibitors In a session on the role of protein kinases in airway ... effects in Cilomilast treated patients were generallyself-limited and mild to moderate in intensity. In a separatestudy in the clinic, Dr J Kelly (GlaxoSmithKline, UK) lookedat the possibility of...

Báo cáo y học: "Black Hawk Down: The evolution of resuscitation strategies in massive traumatic hemorrhage" doc

... work is one of generalizeablity, since the patient population consisted of young, otherwise healthy men suffering primarily penetrating injuries from combat trauma. Whether these findings translate ... after the institution of an early goal directed therapy protocol calling for a 1:1 ratio of plasma to RBCs within the first 6 hours of injury [10]. Sperry and colleagues retrospectively examined ... pressure of 70 mmHg had already lost 67% of their blood volume [6]. Preventing the development of profound and often refractory coagulopathy in these patients required plasma infusion before, instead...

Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

... might in turn result in the uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy ... experience with the management of disseminated disease is very limited in the literature6, therefore, attention to the therapy strategy of this neoplasm in the future may allow a more reasonable ... 4-20). Nine patients had their tumors within the head, 2 in the body and 7 in the tail of the pancreas. Notably one patient was demonstrated to have liver metastasis. The predominant presenting...

Báo cáo y học: "Strength training improves muscle quality and insulin sensitivity in Hispanic older

... In order to investigate the mechanisms leading to improved insulin sensitivity with exercise training, it is necessary to analyze some of the components of the insulin signaling pathway in ... trained showed increased levels of adiponectin. Interestingly, other studies investigating adiponectin levels have shown varying results. High intensity endurance training in nondiabetic individuals ... leading to a training effect including increased protein content of GLUT4, insulin receptor, glycogen synthase and protein-kinase B (PKB) without an increase in muscle mass. However, they could...

Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"

... pass oocysts in their feces. They become infected by eating infected rodents, birds, or other small animals. Once oocysts are shed, they re-quire 1 to 5 days to sporulate and become infective. ... oocysts for only 2 to 3 weeks following primary infection. Mature cats are less likely to shed Toxoplasma if they have been previously infected. Litter box hygiene is the main precaution in ... follow a few very simple “rules”, liv-ing with their pets need not represent any risk for infection with Toxoplasma gondii. Cats are the definitive host of T. gondii; they are the only animals...

Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study" pps

... priori hypothesis was that the birth order effectmay interact with the genetic predisposition of the off-spring in influencing future atopic manifestations. In order to test this hypothesis, ... Each of these SNPs had a minor allelefrequency ≥ 19%.Using the Haploview program [26], three of the fivesingle nucleotide polymorphisms (SNPs) of the interleu-kin 13 gene were in a linkage ... have it s ori-gin in utero [12], before an y hygiene effect in earlychildhood could affect the offspring. In addition, wefound that the number of live offspring significantlyreduces maternal...

Báo cáo y học: "Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states." ppt

... 4).Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampusFigure 3Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampus. Handling resulted in increased ... with hypofunctioning of the sero-toninergic system. Recently BDNF has emerged as a majorfactor in the pathophysiology of depression: BDNF mRNAis increased in the rat brain following chronic anti-depres-sant ... evidence indicates that among the serotonin recep-tors, the type 1A are involved in the etiopathogenesis of certain types of depression [23,24] and is the one throughwhich the therapeutic effects of...

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