Báo cáo y học: "Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies" docx

... aim of the study to extend the limits of the detections. Future improvements in the accuracy and cover- age of annotations are likely to improve also the reliability of the exon array results. The ... is applicable to any existing or future annotation scheme. In addition to the annotation accuracy, another challenging issue in the detection of differen...

Ngày tải lên: 14/08/2014, 21:20

... every 6 to 8 hours) or by continu- ous infusion (3 to 4 IU/kg/hour) [2]. The Bethesda assay was not immediately available in our case and the lack of another bypass agent in the setting of severe ... adjusted depending on plasma FVIII levels and bleeding symp- toms [2]. Another interesting finding in our case was the p resence of persistent melena for two weeks in the...

Ngày tải lên: 11/08/2014, 03:20

... use in acquired hemophilia in the US [2]. By directly activating FX on the surface of activated platelets at the site of injury (thereby bypassing FVIII and FIX), rFVIIa can circum- vent the ... extensively in congenital hemophilia [4], we describe only the sixth cas e of use of aminocaproic acid in a setting of acquired hemophilia [4-8]. We found only one other ca...

Ngày tải lên: 11/08/2014, 07:20

... delivered directly into the airways, can be transformed by esterase cleavage into the active metabolite (R-M1) producing high local anti-inflammatory activity. The anti-inflammatory effi- cacy of Ciclesonide ... increased the secretion of serous mucus in mouse trachea as well as reducing LPS-induced neutrophilia in rats and pigs. Kinase inhibitors In a session on the role...

Ngày tải lên: 12/08/2014, 18:20

... work is one of generalizeablity, since the patient population consisted of young, otherwise healthy men suffering primarily penetrating injuries from combat trauma. Whether these findings translate ... after the institution of an early goal directed therapy protocol calling for a 1:1 ratio of plasma to RBCs within the first 6 hours of injury [10]. Sperry and colleagues...

Ngày tải lên: 13/08/2014, 11:22

... might in turn result in the uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy ... experience with the management of disseminated disease is very limited in the literature 6 , therefore, attention to the therapy strategy of this neoplasm in...

Ngày tải lên: 25/10/2012, 11:40

... In order to investigate the mechanisms leading to improved insulin sensitivity with exercise training, it is necessary to analyze some of the components of the insulin signaling pathway in ... trained showed increased levels of adiponectin. Interestingly, other studies investigating adiponectin levels have shown varying results. High intensity endurance training in non...

Ngày tải lên: 31/10/2012, 15:28

... pass oocysts in their feces. They become infected by eating infected rodents, birds, or other small animals. Once oocysts are shed, they re- quire 1 to 5 days to sporulate and become infective. ... oocysts for only 2 to 3 weeks following primary infection. Mature cats are less likely to shed Toxoplasma if they have been previously infected. Litter box hygiene is the main precaution...

Ngày tải lên: 03/11/2012, 11:06

... priori hypothesis was that the birth order effect may interact with the genetic predisposition of the off- spring in influencing future atopic manifestations. In order to test this hypothesis, ... Each of these SNPs had a minor allele frequency ≥ 19%. Using the Haploview program [26], three of the five single nucleotide polymorphisms (SNPs) of the interleu- kin 13 gene...

Ngày tải lên: 08/08/2014, 21:20

... 4). Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampusFigure 3 Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampus. Handling resulted in increased ... with hypofunctioning of the sero- toninergic system. Recently BDNF has emerged as a major factor in the pathophysiology of depression: BDNF mRNA is incr...

Ngày tải lên: 08/08/2014, 21:20