Báo cáo y học: "Closing gaps in the human genome using sequencing by synthesis" pps
Báo cáo y học: "Closing gaps in the human genome using sequencing by synthesis" pps
... can be attacked by the
methodology of carefully reassembling existing tiling paths or
by reassembling the area using a single haplotype, as
described previously [2,3]. The three gaps closed here ... Genome Biology 2009, 10:R60
Open Access
2009Garberet al.Volume 10, Issue 6, Article R60
Method
Closing gaps in the human genome using sequencing by synthesis
Manuel...
Báo cáo y học: "A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation" potx
... homozygotes, as indicated by our ex
vivo study (Figure 2). This observation is in full accordance
with the finding that the His
452
tyr substitution in the 5-HTR
2A
gene is accompanied by a reduced ... which the enzymes were deactivated by
incubation at 80°C for 15 minutes. Samples were sequenced
in both directions on an Applied Biosystems 3100 Genetic
Analyzer using th...
Báo cáo y học: "Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation" docx
... studied by determining
alveolar enlargement, heart hypertrophy, inflammatory
cells in the bronchoalveolar lavage fluid (BALF)
and lung tissue and by analyzing the cytokine and che-
mokine profiles in ... is
regulated by the release of different mediators, including
proteases, cytokines and chemokines secreted by a vari-
ety of inflammatory and resident ce lls. These mediator...
Báo cáo y học: "Delirium assessment in the intensive care unit: patient population matter" ppsx
... also varied. These ICU
delirium screening instruments differ in the components of
delirium they evaluate, in their threshold for diagnosing
delirium, and in their ability to be used in patients ... change in cognition that develops over a short
period of time and fluctuates during the course of the day.
There also must be evidence from the history, physical exami-
nation, or...
Báo cáo y học: " Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates" ppt
... Gag-Pro-Pol
monomer may be constrained by the excess of Gag during
assembly, as suggested by others [47-49]. In that case, the
presence of Gag could limit Gag-Pro-Pol dimerization by
forming heterodimers, in turn ... dimerization of the
PR and RT domains may serve as a regulatory element to influence the kinetics of processing within
the Pol domain.
Findings
The retrovir...
Báo cáo y học: "Conservation anchors in the vertebrate genome" pdf
... constraint in intergenic regions of human and mouse
genomes. Trends Genet 2001, 17:373-376.
9. International Human Genome Sequencing Consortium: Initial
sequencing and analysis of the human genome. ... human) was proposed years ago as the best
candidate for identifying human ANCORs [3], but only
recently has the full genome sequencing of this species been
accomplis...
báo cáo khoa học: " LINE dancing in the human genome: transposable elements and disease" ppt
... of
the extracellular environment.
The increasing ease of sequencing genomes is likely to help
clarify the extent of the contribution of mobile elements to
genetic instability in many human ... etiology, explain this increase. Here, we
focus on the most recent advances in understanding of the
impact of the active human TEs on the stability of the human
genome...
báo cáo khoa học: " Inversion variants in the human genome: role in disease and genome architecture" ppsx
... under-
standing of the extent of inversion variants in the human
genome has increased dramatically in the past few years.
is review will give an overview of the current
knowledge of inversions in the ... gene or regulatory
function is interrupted by the breakpoints, inversions
that are comparatively large may be frequent in the
population. While there are ver...
Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... portacaval shunting, thereby decreasing first pass
metabolism; decrease in quantities and affinity of plasma
proteins, thereby increasing free-drug levels; increase in
volume of distribution in patients ... bipolar disorder in the
general population are likely receiving even less medical
care. The significance of this finding is that the psychiatrist
may be the only physician...
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... continuously being identified,
and these polymorphisms may play a pivotal role in
sporadic carcinogenesis. A growing body of literature,
including observations of inter-individual differences
in ... located in the
vicinity of the translation initiation codon, it may alter
translation efficiency. The nearby proximal nucleo-
tides to the AUG initiation codon are important for...