Báo cáo y học: " DNA breaks as triggers for antigenic variation in African trypanosomes" doc

... previously active. The former is the dominant mechanism underlying antigenic variation [4], and is the focus of new work reported recently in Nature by Boothroyd et al. [5]. As double-strand breaks ... david.horn@lshtm.ac.uk AAbbssttrraacctt The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a d...

Ngày tải lên: 14/08/2014, 21:20

... ML: Tranexamic acid attenuates inflammatory response in car- diopulmonary bypass surgery through blockade of fibrinoly- sis: a case control study followed by a randomized double-blind controlled trial. ... cardiopulmonary bypass: participation of interleukin 8 and 6 in reperfusion injury. Can J Anaesth 1993, 40:1016-1021. 5. Laffey JG, Boylan JF, Cheng DC: The systemic inflammatory respon...

Ngày tải lên: 13/08/2014, 08:21

... homo- zygosity of deleterious mutations may explain the repeated success of asexuals in nature [32]. Whereas any new insertions in a sexually recombining genome can become homozygous, asexuals carry ... Coordination infrastructure for the DGC is provided by The Center for Genomics and Bioinformatics at Indiana University, which is supported in part by the METACyt Initiative of India...

Ngày tải lên: 09/08/2014, 20:21

... capacity were evaluated at baseline and after 12 weeks of training with three training sessions per week. The main findings are: Fasting glucose concentrations remind unchanged after training. ... significance. Moreover, in the control group (flexibility training) and the strength training group HbA1c increased by 5 % and 3 %, respectively. This finding is clearly inconsistent with the...

Ngày tải lên: 26/10/2012, 10:04

... suggesting the importance of DNA methylation and TLR9 in autoimmunity, two common medications frequently associated with drug-induced SLE, namely hydralazine and procainamide, inhibit DNA methylation ... activate EKR1, may leak nucleic acid containing immunostimulatory complexes more readily, and induce inflammatory signals in part by releasing high mobility group box (HMGB) proteins...

Ngày tải lên: 09/08/2014, 10:21

... measurement of endothelial function is highly dependent upon current levels of inflammation. In healthy people, the inflammatory response elicited by vaccination is sufficient to temporarily ... (and reversibly) impair endothelial function [7]. Reduction of inflammation using anti-TNF therapy in RA is rapidly (although transiently) followed by improvement of the endothelial function [8]....

Ngày tải lên: 09/08/2014, 10:22

... reported that invasive tenosynovium is more hypoxic than noninvasive RA tenosynovium, or indeed than normal ten- osynovium [12]. Intriguingly, hypoxia has been shown to upregulate gelatinases (MMP-2 ... hypoxia-induced gene in car- cinoma cells [33]. The objective of our study was therefore to examine the poten- tial in vivo consequences of hypoxia in RA in terms of synovial invasion,...

Ngày tải lên: 09/08/2014, 14:20

... Maher and Arul Chinnaiyan for providing us with their RNA-seq data. Thanks to Lou Staudt for invaluable feedback on early versions of TopHat-Fusion, to Ryan Kelley for his indel- finding algorithm, ... originally found in the MCF7 cell line in 2002 [22]. As illustrated in the figure, many reads clearly span the boundary of the fusion between chromosomes 20 and 17, illustrating t...

Ngày tải lên: 09/08/2014, 23:20

... from 37 percent in Texas to almost 70 percent in New Jersey [22,23]. Secondly, rising utilization can be explained by declining mortality rates, leading to individuals' requiring more pre- scriptions ... for by Medicaid increased from 168,914 in 1991 to 3.0 mil- lion in 2005, showing a 16.7-fold increase over 15 years (see Table 2). In 1996, and again in 1997, utilization o...

Ngày tải lên: 10/08/2014, 05:20

... HIV infection in individuals ≥50 years of age is rapidly increasing [4, 5], yet there is evidence that this older age group may not be as aware of HIV infection and the need for preventive measures ... for initiating high ly activeantiretro- viral therapy (HAART) [1,2]. Over the study period, there was an increase in the median age at first presen- tation for HIV care (from 40 to...

Ngày tải lên: 10/08/2014, 05:21