Báo cáo y học: " The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress" ppt

... exclusively required for the repression or for the induction of the ESR genes but instead is required for proper changes in the genes' expression regardless of the directionality of the change. Discussion Our ... observed in cells harboring a mutant histone H4 (H4KQ), in which amino-terminal lysines were changed to glutamine to mimic the acetylat...

Ngày tải lên: 14/08/2014, 21:20

... Prud'homme GJ: Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors. J Gene Med 2000, 2:222-232. 16. Abdi K: IL-12: the role of p40 versus ... Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A: Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and ind...

Ngày tải lên: 11/08/2014, 08:21

... transcription. Instead, a coordinated balance in their activity is required for the functional output of transcription factors. Histone deacetylases and histone deacetylase inhibitors The human genome ... in arthritis. Of particular interest to the clinical setting is the finding that a subset of these compounds may be therapeutically useful in established arthri...

Ngày tải lên: 09/08/2014, 11:20

... chromatin is the nucleosome, formed by the wrapping of DNA around an octamer of core histone proteins. By restricting the access to DNA-binding factors and impeding elongation by RNA polymerase ... modulated by the covalent modifications of the N-termini of the core histones in nucleosomes and by the action of ATP- dependent chromatin remodeling complexes. In particu-...

Ngày tải lên: 13/08/2014, 06:20

... phosphorylation of the 3-hydroxyl group of shikimate using ATP as the phosphoryl donor [13,14], is a member of this subclass. This step is the fifth in the seven-step pathway leading to the synthesis ... (1995) The structure of the transition state for folding of chymotrypsin inhibitor 2 ana- lysed by protein engineering methods: evidence for a nucleation- condensatio...

Ngày tải lên: 08/03/2014, 23:20

... becoming an urgent problem in developing countries owing to the worldwide increase in obesity [2]. Therefore, there is considerable effort to understand the underlying biology of these disease ... MCP-1 me- diates the infiltration of macrophages into WAT in obesity and may play an important role in establishing and maintaining a proinflammatory state that predis- pose...

Ngày tải lên: 08/08/2014, 17:20

... and safety Levocetirizine is a potent antihistamine as demonstrated by its ability to inhibit cutaneous histamine-induced itch- ing and the wheal and flare reaction [3-5]. The histamine- induced ... of numerous vasoactive and pro-inflammatory mediators in addition to histamine. The authors evaluated the inhibi- tory activity of levocetirizine and desloratadine on the allerge...

Ngày tải lên: 08/08/2014, 21:20

... viability Monolayers were harvested by trypsinisation and viable cell counts were performed using trypan blue. The proliferation status of cells was also examined by immunocytochemistry for the proliferation-associated ... intervertebral disc (IVD) is thought to play a major role in disc pathophysiology by limiting nutrient supply to resident IVD cells. In the human IVD, th...

Ngày tải lên: 09/08/2014, 10:23

... found in the synovial sublining. Initial qualitative analysis of RasGRF1 expression in RA and inflammatory OA synovial tissue suggested that RasGRF1 expression was elevated in RA synovial tissue ... cells/mm 2 were obtained for both the intimal lining layer and the synovial sublining, and were corrected for total number of nucleated cells/mm 2 . Immunohistochemical double...

Ngày tải lên: 09/08/2014, 14:22

... model. The mechanism for the differences in response to siRNA in disc height and MRI findings may be worthy of exploration. Competing interests The authors declare that they have no competing interests. Authors' ... that in the AF. In addition, the direct injection of siRNA into the NP may induce a localized improvement. It is worth noting that the histologi...

Ngày tải lên: 09/08/2014, 14:22