Báo cáo y học: "Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease" docx

... These subnetworks are very close to each other, with C2 appearing to play a more central role (Figure 4). Two other highly asymmetric subnetworks emerge from the AH analysis: C5, containing the hypothalamus ... cis-eQTL. Two types of subnetworks are observed in the network: type 1 subnetworks that contain genes located on the same chromosome that also have cis-eQTLs; and type 2 su...

Ngày tải lên: 14/08/2014, 21:20

... are associated with mania symptoms in outpatients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:952-955. 58. Bazar KA, Yun AJ, Lee PY, Daniel SM, Doux JD: Obesity and ... with children without asthma [25]. A previous study on adults, with data from a large claims database in the USA, showed that ADHD was significantly associated with asthma [26]. In a...

Ngày tải lên: 11/08/2014, 15:22

... percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes combined (CD3 + + CD19 + lymphocytes). The CD19 percentages found in RA patients showed a bimodal distribution, with two separate ... frequency peaks (B-cell low patients and B-cell high patients) were separated by the population median of a B-cell frequency of 8.5% of all lymphocytes. Human leucocyte antigen genoty...

Ngày tải lên: 09/08/2014, 03:24

... by relaxin but not by estrogen is accompanied by loss of glycosaminoglycans (GAGs)Induction of matrix metalloproteinases by relaxin but not by estrogen is accompanied by loss of glycosaminoglycans ... pubic symphysis and articular cartilage explants was similarly subjected to western blot analysis for collagenase-1 and stromelysin-1. Substrate zymography Enzyme activities were quantified by s...

Ngày tải lên: 09/08/2014, 06:22

... Detector System (Applied Bio- systems, Foster City, CA, USA). Data were processed using the SDS 2.1 software (Applied Biosystems). The different genotypes were verified by comparison with control ... onset of the disease compared with patients without these autoantibodies (n = 150) (53.2 years for patients with anti-CCP antibodies and 56.8 years for patients without anti-CCP antibodies,...

Ngày tải lên: 09/08/2014, 10:20

... linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR- restriction fragment length polymorphism in 100 French Caucasian ... SNPs to refine the associated haplotype. In the same way, the chromosome 2 linkage suggestion observed in the genome scan of our laboratory could not be totally explained by the findings...

Ngày tải lên: 09/08/2014, 10:20

... of our study include the community-based recruit- ment of asymptomatic women, the relatively large number of study participants, and measurement of CRP by a highly sen- sitive assay. A potential ... possibility that CRP levels may have been affected by intercurrent illness, women were asked not to attend for their blood test on a day they were not well. Another limitation to our study is that...

Ngày tải lên: 09/08/2014, 10:23

... prednisolone only, methotrexate only, sulfasalazine only, hydroxychloroquine only, tumour necrosis factor-blocking agents, combination of disease-modifying antirheumatic drugs, pack-years, smoking, erosions, ... body mass index; CRP, C-reactive protein; DAS28, disease activity score using 28 joint counts; DMARD, disease- modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ,...

Ngày tải lên: 09/08/2014, 14:22

... support grant (grant number 17682, given to the Dudley Group of Hospitals NHS Foundation Trust, Department of Rheumatology). HJ is supported by an Arthritis Research Campaign Educational Research ... VFP is supported by a PhD scholarship from the Empirikion Institute, Athens, Greece. References 1. Toms TE, Panoulas VF, Douglas KMJ, Kitas GD: Methotrexate therapy associates with a reduced pr...

Ngày tải lên: 09/08/2014, 14:22

... are usually associated with neurofibromatosis type 1. They are almost always congenital lesions and often cause the surrounding soft tissue and bone to grow aberrantly. We treated a 12-year-old boy who ... nerve sheath.Theyareusuallycongenital,buttheymay instead present during the first year as a subtle soft-tis- sue enlargement or a large patch of cutaneous hyperpig- mentation. PNFs are...

Ngày tải lên: 10/08/2014, 09:22