Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx

... intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data Yvonne JK Edwards ¤ , Anna E Lobley ¤ , Melissa M Pentony and David T Jones Address: Bioinformatics ... original work is properly cited. Intrinsically disordered proteins& lt;p>Signals for microRNA targeting and ubiquitination are enriched in intrins...

Ngày tải lên: 14/08/2014, 21:20

... the initiation of the study. They greatly acknowledge the expert assistance of Franck Lager for breeding and husbandry of the mice, and the collaboration of the staff of the Central Cytometry ... All of these T cells strictly recognized the carbohydrate moiety linked to Hyl 264 within the CII256–270 epitope because they were activated neither by the ung...

Ngày tải lên: 09/08/2014, 10:21

... density and the number of myelinated fibres was compared to the functional index, as in the experimental group with the lowest number of myeli- nated fibres and the lowest fibre density per mm, ... or by Meek [40] utilizing video analysis and taking both dynamic and static gait parame- ters into account are promising. As already proposed by Geuna [41], we recomme...

Ngày tải lên: 10/08/2014, 10:20

... by Nurr1; many of these are involved with the devel- opment and maintenance of midbrain dopaminergic neurons. These include tyrosine hydroxylase [4], Ret tyro- sine kinase [15] and the dopamine ... study was to further investigate the role of Nurr1 in regulating inflammatory processes in syn- ovial cells, and by using transcript profiling to identify Nurr1 regulated...

Ngày tải lên: 11/08/2014, 08:21

... ears of each mouse by the topical application of 2 µg TPA dissolved in 20 µL of ace- tone to both the inner and outer ear surfaces. Thirty min- utes after the application of TPA, the inner and ... care and Emily Kelso for obtaining the chromatogram. We thank Dr. Ron Pegg, Dept. of Food Science and Technology, University of Georgia, for analyzing the con...

Ngày tải lên: 11/08/2014, 08:21

... was having all involved doctors trained within six months. We evaluated the course by asking the doctors about their approach to deciding on and performing retroperitoneal packing. Finally, we ... mon- itored the changes in the number of procedures per- formed after the course and the outcome of the trauma audits. Materials and methods Hands-on training of retrop...

Ngày tải lên: 13/08/2014, 23:20

... separately aligned with the sequences of 1CEV and 1RLA and pasted into the structural alignment. The alignment was then corrected by hand. Since the sequences of the two arginases and agmatinase ... coli agmatinase, of the loop indicated by the letter a. Fig. 5. Scheme of the binuclear manganese cluster and the localization of the side-chains of A...

Ngày tải lên: 21/02/2014, 01:21

... importance, and they have long been a model for biological research in fields ranging from embryology and development to virology and cancer. In addition, the phylogenetic position of the chicken, ... to find conserved sequence elements, which may include previously unknown genes. The divergence of the compared genomes will determine the type of conservation found....

Ngày tải lên: 14/08/2014, 14:21

... levels of proinflammatory cytokines and symptoms of RA, such as morning stiffness [11,12]. Several of these cytokines are highly elevated in patients with active RA in the early hours of the day, ... drugs at least in rheumatoid arthritis (RA) [1,6]. In addition, mild exercise and training and a decrease in the proinflammatory load – as obtained also by the u...

Ngày tải lên: 09/08/2014, 13:22

... 11:150 http://respiratory-research.com/content/11/1/150 Page 14 of 15 The data demonstrate there is expression of genes for a complete GABAergic system in the airway epithelium. Interestingly, the expression of GAD67 was markedly modified by smoking, ... Assessment of our database of airway epithelial gene expression generated by micro- arrays showed that, while...

Ngày tải lên: 12/08/2014, 11:22