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Báo cáo y học: "A whole-genome assembly of the domestic cow, Bos taurus" potx

Báo cáo y học:

Báo cáo y học: "A whole-genome assembly of the domestic cow, Bos taurus" potx

... one assembly, and all other reads (at leastthree) confirmed the other assembly. The UMD2 assembly contains 10,636 instances of these apparent errors versus30,750 in the BCM4 assembly. Thus, there ... library (Materials andmethods), only a very limited amount of the assembly can beassigned to the Y chromosome. (It is worth noting here that the BCM4 assembly does not assign any sequence to the ... an improved assembly "greatly improves the precision of biological analyses including studies of gene number, birthand death."To assemble the genome of the domestic cow, Bos taurus,...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

... C-terminally to the CBM that playspecific roles in activation of the receptor by these twocytokines. The ligand independent activation of the D5-GCSFRchimera occurs in both the absence and the presence ... copre-cipitation of gp130 with LIFR independently of the lysisbuffer used for the disintegration of the cells (data notshown). Because of the high expression levels of the transiently transfected ... a system that allows the study of gp130mutants together with the LIFR in COS7 cells despite the presence of low amounts of endogenous wild-type receptors.To achieve this, the cytoplasmic tyrosine...
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Báo cáo y học:

Báo cáo y học: "A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer." pps

... lacking glycosylation [26]. In the first part of the present study similar end-point levels of transgenic and recombinant IL-1Ra were necessary toinhibit fully the response of synoviocytes to ... vivoconcentrations of IL-1Ra in a sustained manner may bekey to realizing the full therapeutic potential of this mater-ial. Gene delivery may offer the greatest chance of earlysuccess. Recent ... rIL-1Rawas unable to block the effects of persistent IL-1β produc-tion. Even at the highest dose, the steady dilution of rIL-1Ra in the presence of constant IL-1β synthesis rapidlylost its protective...
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Báo cáo y học:

Báo cáo y học: " A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population" pps

... polyarthritis and systemic subgroups, the frequency of haplotype S01 did not differ statistically from that of healthy controls. The frequency of haplotype S01 was alsosignificantly higher in the patients ... fre-quency of haplotype S01 of the IL18 gene is 37.9% and that of the S01/S01 diplotype configuration is 13.9% in the Japa-nese population. We also estimated the frequency of haplo-types and/or the ... identified some of thesepolymorphisms as components of haplotypes and found therewere three major haplotypes in the Japanese population (S01,S02, and S03). Furthermore, the frequency of haplotype S01,especially...
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Báo cáo y học:

Báo cáo y học: "A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis" doc

... identification of new lymphoma casesbased on consultation between rheumatology and oncologydepartments. Uncertainty regarding the size of the RA popula-tion evaluated may account for their very high ... relativerisk of 7.4 for Hodgkin lymphoma. Sources of selection biasmay include the use of hospitalization records for identification of populations.Other limitations include the possibility of misclassificationand ... misclassificationand the wide variation in follow-up. There may have been mis-classification of the inclusion of patients into the RA popula-tions, and there may have been uncertainty surrounding the diagnostic...
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Báo cáo y học: "A meta-analysis of the efficacy of fibromyalgia treatment according to level of care" pptx

... by the heterogeneity of the studies. Othervariables that also improved outcome and were not biased by the heterogeneity of the studies, were younger age of the patients and shorter duration of ... homogeneity. In any case, the study pointsto moderate efficacy of any of the treatments described forfibromyalgia and similar efficacy in both primary and special-ised levels of care.Two of the ... primary carefor any of the seven outcomes or the many questionnairesassessed. In the case of quality of life, the two levels of carecould not be compared. We consider that the external validityof...
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Báo cáo y học:

Báo cáo y học: "A Rasch Analysis of the Manchester Foot Pain and Disability Index" pdf

... Table 1shows the fit of the individual items. There was no misfitas measured by the item residuals or the chi-square fit sta-tistic in either of the subscales, after applying the Bonfer-roni ... disability of the sample. A mean personlocation of zero indicates that the items and the sampleare perfectly targeted. The Person Separation Index (PSI) was considered as ameasure of the ability of ... are shown inTable 1. These locations allow the ordering of the items interms of the difficulty of the tasks to which they pertain. The first item in the function scale is Item 6 (avoid walk-ing...
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Báo cáo y học:

Báo cáo y học: "A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pdf

... validity. In spite of this strength, they still bothshare many of the same limitations and concerns, asnoted above. In the case of the hand hygiene study [24], the authors do not specify what statistical ... Periodicals Directory and the publica-tion's website. These liberal criteria allowed for the inclu-sion of almost any study design, analytic strategy,outcome of interest, or type of health service ... history and expectation of research, therebyappearing to be natural settings for these types of investi-gations. Evaluation of these and other transformativestrategies may be slightly different...
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Báo cáo y học:

Báo cáo y học: " A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations" pps

... of all instances of the- ory use. Fourteen studies used 11 theories explicitly.Only two theories were used explicitly more than once. The PRECEDE theory was also the most commonlyemployed theory ... 2 of 6choice of theory used and devel op a clear rationale of how the theory is proposed to operate within the study.Where possible, hypotheses deduced from the theory todesign t he study ... where a theory was judged to have been usedwithin the study, but where the study did not provide atest of any of the hypoth eses deduced from the theory inorder to design the study. Studies...
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Báo cáo y học:

Báo cáo y học: "A systematic review of the international published literature relating to quality of institutional care for people with longer term mental health problems" potx

... clarity of the research question or hypothesis, the type of methodologyused [16] and relevance of the participants to the aims of the review); (4) data analysis (which included clarity of the ... based medicine; psychiatricrehabilitation; rehabilitat*; activities of daily living; arttherapy; bibliotherapy; dance therapy; exercise therapy;music therapy; occupational therapy; rehabilitation, ... Characteristics and quality of studies included in interventions domain: Compliance therapyStudy (Country) Type(s) of Mental Illness Number of Participants Type of Study(Type of Setting)Quality AssessmentEckman...
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