Báo cáo y học: "The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation" pot

... R40 Method The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation Hideya Kawaji * , Jessica Severin * , Marina Lizio * , Andrew Waterhouse * , Shintaro Katayama * , ... derived from 41 RNA samples taken in FANTOM3 [3]. In contrast to the relatively shallow sequencing of the FANTOM3 CAGE data, the FANTOM4 deepCAGE data sample suf...

Ngày tải lên: 14/08/2014, 21:20

... superoxide to oxidative stress from hydroxyl and alkoxyl radicals. LDL oxidation may play a key role in atherosclerosis [41]; more generally, however, slightly oxidized LDL is readily imported by most cell ... for maintaining ATP supply, mammalian cells cannot emulate yeast’s ability to Ôbalance the booksÕ with regard to redox state by reducing glycolysis-derived pyruvate to lacta...

Ngày tải lên: 17/03/2014, 23:20

... ferrous complex was mainly formed through reduction of free a-hydroxyhaem by dithionite followed by its direct binding to the enzyme, rather than by reduction of the enzyme-bound ferric a-hydroxyhaem, as no ... degradation system driven by NADPH-cytochrome P450 reductase. Keywords: haem oxygenase; a-hydroxyhaem; verdohaem; sodium dithionite; NADPH-cytochrome P450 reductase. Microsomal hae...

Ngày tải lên: 23/03/2014, 21:20

... of MBP, together with its propensity to “ stick” to virtually any substratum as well as its near insolubility in environ- ments at neutral pH limits its utility for immunohist o- chemistry [12]. ... patient may have had a variant of a lymphocytic hypereosinophilic syndrome given the systemic eosinophilia, modestly high levels of sputum IL-5 and serum TARC and raised serum total IgE...

Ngày tải lên: 08/08/2014, 21:20

... nodules, 4 with vasculitis only, 1 with vasculitis and amyloidosis, and 2 with sicca syndrome and amyloidosis. Amyloidosis was diagnosed by histomorphology (in biopsy specimens from skin and bowel or ... functionally active and have the ability to release cytokines in the absence of a costimulatory pathway. CD4 + CD28 – T cells contribute to the cell infiltrate and exhibit increased sur...

Ngày tải lên: 09/08/2014, 01:22

... instruments vary in perfor- mance, not only with respect to intralaboratory configura- tions, but also with respect to interlaboratory configurations. A key element related to microscopy is the use ... standards. Meanwhile the industry is advancing quickly to adapt, to modify, and to advance diagnostic technologies as well as offer new diagnostic kits to make the laboratory clin...

Ngày tải lên: 09/08/2014, 01:23

... previously been shown to exhibit a pronounced inhib- itory activity. To analyse the influence of clinical parameters of disease activity on the inhibitory activity exhibited by the sera from patients ... preserved the inhibitory activity, whereas increasing the temperature to 70 or 95°C resulted in a loss of that inhibitory activity. Thus, the inhibitory activity is due to heat-labi...

Ngày tải lên: 09/08/2014, 07:20

... rheumatoid foot. Jof Tissue Viability 2004, 14(4):137-41. 3. MacSween A, Brydson GJ, Hamilton J: The effect of custom moulded ethyl vinyl acetate foot orthoses on the gait of patients with rheumatoid arthritis. ... inten- sity, activity limitation and personal appearance, the MFPDQ may not adequately capture the psychosocial experiences of patients arising from pain and disability in their...

Ngày tải lên: 10/08/2014, 21:24

... Access Study protocol The QICKD study protocol: a cluster randomised trial to compare quality improvement interventions to lower systolic BP in chronic kidney disease (CKD) in primary care Simon ... frequently asked questions, and tools to improve CKD management. The GaP documentation will typically be up to four sides of A4 paper stock, published in a glossy professionally printed...

Ngày tải lên: 11/08/2014, 05:21

... Nakane Y, Sartorius N, Shen Y, Skoda C, Thara R, Tsirkin SJ, Varma VK, Walsh D, Wiersma D: Recovery from psychotic illness: a 15- and 25- year international follow-up study. Br J Psychiatry 2001, 178:506-517. 10. ... sig- nificantly later in the six year study period and had already spent significantly longer in hospital. Risk factors A history o f self har m or s uicide attempts was sign...

Ngày tải lên: 11/08/2014, 15:22