Báo cáo y học: "Transcriptional features of genomic regulatory blocks" pdf

... number of unique features that are the likely cause of their ability to respond to regulatory inputs from very long distances. Background It has been demonstrated recently that the loci of many key developmental ... likely cause of their ability to respond to regulatory inputs from very long distances.</p> Abstract Background: Genomic regulatory blocks (GRBs) are chrom...

Ngày tải lên: 14/08/2014, 21:20

... Wathelet 1 1 Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati; 2 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA Virus ... P31 ·2 CAT reporter, which is driven by the IRF-dependent element of the IFN-b gene promoter. This reporter is only weakly inducible by virus alone because of the relative...

Ngày tải lên: 17/03/2014, 10:20

... differen- tiation in erythroid progenitors. Polycytemia vera is a clonal myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... survival of early hematopoietic cells, at the expense of differenti- ation. The proto-oncogene c-Myb c-Myb is abundantly expressed in immature hematopoietic cells of erythr...

Ngày tải lên: 08/03/2014, 22:20

... Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflamma- tory cytokines. Arthritis Rheum 2001, 44:1096-1104. 64. Suh N, Wang Y, ... primary rabbit synovial fibroblasts, only IL-1 is capable of inducing MMP-1 transcription [29]. This is due, in part, to the inabil- ity of TNF to activate the ERK pathways in these c...

Ngày tải lên: 09/08/2014, 03:24

... Loss of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 ... amino-terminal region of KLF17. Given that the activity of some Sp1/KLF family members is known to be regulated by PKC isoforms [8,24-26], it is plausible that the ability of KLF17 to...

Ngày tải lên: 09/08/2014, 20:20

... phenotype. The aim of this study was to utilise Affymetrix microar- ray technology to identify novel bovine marker genes that could be used to discriminate the transcriptional profile of chondrocyte-like ... basic cytokeratin [40]. Members of the cytokeratin family are typically expressed by epithelial cells but are found in a wide range of tissues [41], including the developing NC [4...

Ngày tải lên: 12/08/2014, 11:23

... is one of the key features of systemic scle- rosis (SSc) (scleroderma), a prototypic fibrotic condition * Correspondence: carlo.chizzolini@unige.ch 1 Immunology and Allergy, Department of Internal ... 12:R73 http://arthritis-research.com/content/12/2/R73 Page 12 of 14 of SSc dermal fibroblasts [39]. It is therefore likely that the effect of bortezomib on type I collagen synthes...

Ngày tải lên: 12/08/2014, 12:20

... marker of the ontology of the cells of the nucleus pulposus is the T-box gene brachyury, which is required for diff erentiation and survival of the notochord [9]. Similarly to profi ling studies of ... replacement of them by unrelated cell types or to both [2].  is dispute aff ects investigational strategies in which the choice of animal model for a study is governed by the...

Ngày tải lên: 12/08/2014, 12:20

... genes. Homozygous functional deletion of Smad4 results in early embryonic lethality before embryonic day 7.5 [26]. Smad5 –/– embryos die between embryonic days 9.5 and 11.5, but lung abnormalities ... lineage history of alveolar type I and type II cells is unknown. Among a number of biochemical and morpho- logical criteria, alveolar type II cells are defined by the syn- thesis of surf...

Ngày tải lên: 12/08/2014, 18:20

... 2004, 78:13901-13910. 18. Liu Y, McNevin J, Zhao H, Tebit DM, Troyer RM, McSweyn M, Ghosh AK, Shriner D, Arts EJ, McElrath MJ, Mullins JI: Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: ... Goto M, Kitamura Y, Nakamura T, Kelleher AD, Cooper DA, Iwamoto A: Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus...

Ngày tải lên: 12/08/2014, 23:21