Báo cáo y học: " Chromatin conformation signatures of cellular differentiation" doc

... original work is properly cited. Chromatin conformation signatures& lt;p>A suite of computer programs to identify genome-wide chromatin conformation signatures with 5C technology is reported.</p> Abstract One ... local chromatin densities within any given genomic environment, which are then represented graphically. This 5C array analysis of chromatin conformation...

Ngày tải lên: 14/08/2014, 21:20

... an unlikely source of much missing heritability. Of the 95 loci known by SNP studies at the end of 2009 to be associated with Crohn’s disease and type 1 and type 2 diabetes, only three harbored ... nitive studies are awaited, and they may be tagged by SNP studies anyway [4]. Most heritability studies report narrow-sense heritability, which is heritability excluding gene–gene inter...

Ngày tải lên: 12/08/2014, 15:22

... moderately severe ARDS (lung injury score 2.3–3.3) and were studied early in the course of their disease (they had been ventilated for <7 days). Half of the patients had a ‘primary’ cause of ARDS ... Oliveira R, Takagaki TY, Carvalho CR: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syn- drome. N Engl J Med 1998, 338:347-354. 13. Lapinsk...

Ngày tải lên: 12/08/2014, 19:21

... may mask cer- tain Nef phenotypes. For example, the presence of endo- toxin in some serum preparations may alter the cytokine profile of PBMC. In summary, using freshly isolated rather than cry ... pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity. J Biol Chem 2006, 281(28):19618-19630. 34. Wei BL, Arora VK, Raney...

Ngày tải lên: 13/08/2014, 01:21

... thymectomy, and weekly administration of antithymocyte serum so that the skin grafts were not rejected. With the same standard dosage of MCA, most grafts developed papillomas, but about 80% of ... immunodepressed kidney-trans- plant patients [14]. Many, and perhaps all, melanomas arise in benign nevi, many of which may, I hypothecate, be too small to be grossly visible; there is usual...

Ngày tải lên: 13/08/2014, 16:21

... with a methylated genome, confirmed by methylation-sensitive restriction enzymes, can be reactivated by 5-azacytidine, an inhibitor of DNA methylation [6]. In addition, methylation of the HTLV-1 ... expression may correlate more with the density of DNA methylation, as opposed to there being a binary ‘methylated’ or ‘demethylated’ state [36]. What controls the behavior of the chromati...

Ngày tải lên: 14/08/2014, 08:20

... in eukaryotes are more clearly defined, detailed systematic analyses of diversity within eukaryotes on the basis of fully sequenced genomes are precluded by the limited number and phylogenetic ... availability of a fully resolved and robustly timed phylog- eny. Conversely, these data may be usefully combined with additional experimental and theoretical studies to unravel the relative in...

Ngày tải lên: 14/08/2014, 08:20

... probably appeared early in the evolution of eukaryotes, before the separation of animals, plants and fungi. Yeast and several other species of fungi have related proteins of the PalF family [14]. ... regulation of histone acetylation and gene transcription [62]. Knockout of Kurtz, the only non-sensory arrestin in Drosophila, is embryonically lethal, as is the simultaneous knockout...

Ngày tải lên: 14/08/2014, 17:22

... inherent diversity of microbial communities typically limits genomic assembly, resulting in highly fragmentary data [13]; there are few uni- versally conserved phylogenetically informative markers, leaving ... potentially drive changes in the host sequence signatures if they replace or supplement the restric- tion systems of the host. Alternatively, the degree of similarity in tetranu...

Ngày tải lên: 09/08/2014, 20:20

... analyzed conserved TFBSs by two steps at the sequence level, including annotation of orthologous genes and study of the similarity of TFBSs in aligned regulatory regions. We found a majority of the ... assay. Our study sug- gests that integration of genome-wide microarray profiling and computational analyses is a powerful way to identify gene signatures as determinants for cancer...

Ngày tải lên: 14/08/2014, 07:21