Báo cáo y học: "The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes" docx
Báo cáo y học: "Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes" potx
... (- 10 log P values; indicated in grey; the genes in these regions are printed in the boxes). The horizontal red line indicates the multiple testing corrected P value of 0.01, above which the positional ... the cell of origin hypothesis, we performed a series of data mining anal- yses aimed at identifying genes and pathways that may be involved in neuroblastoma...
Ngày tải lên: 14/08/2014, 17:22
Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... by the AIM-C, was also generally improved over the course of the study. At baseline, most caregivers indicated inconsistency in their child's behavior across the day in contrast to endpoint ... social interactions since beginning the study medication, and 91.9% were satisfied with the efficacy of the study medi- cation on their child's attention. The majority...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the associ...
Ngày tải lên: 31/10/2012, 15:37
Tài liệu Báo cáo Y học: Purification, characterization, immunolocalization and structural analysis of the abundant cytoplasmic b-amylase from Calystegia sepium (hedge bindweed) rhizomes ppt
... the activity of the enzyme was measured by the dinitrosalicylic acid method. Inhibition of the enzyme activity by glucose, maltose and cyclohexaamylose For the study of the enzyme inhibition by glucose, ... by the inhibitors of the enzymatic activity. Therefore the iodine staining method is well suited for extensive kinetic analyses of purified b-amylases. Sta...
Ngày tải lên: 22/02/2014, 07:20
Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... As both the E a of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme to the Mn 2þ -containing enzyme, loss of the metal cofactor ... between the buffer and the enzyme by preincubating the enzyme metal mixture at 30 8C for 30 min. Remaining activity was measured with glucose as the substrate...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
... Enhanced Chemiluminescence (ECL) system (Amersham plc). Other assay procedures Rates of protein synthesis were assayed in CHO.K1 cells by measuring the incorporation of [ 35 S]methionine/cysteine into acid-insoluble ... consider their effects on protein synthesis when studying the effects of these stress conditions on cell physiology. Other agents that inhibit protein synthesis (s...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... only partially soluble in five of the constructs resulting in very poor yields. Intriguingly, in the sixth con- struct, the yield of soluble fusion protein with an extended carboxyl terminus of ... solubility of fusion proteins is not necessarily indicative of either proper folding or of increased solubility of the protein of interest. We propose that the succes...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx
... between the CaM-binding domain and the CnB- binding helix and increases the affinity of the CaM-binding domain for Ca 2+ /CaM [25,26]. The regulation of the CaM- binding domain by CnB may partly account ... Ca 2+ - binding to the low affinity sites, the CaM-binding domain interacts with the exposed side of the CnB-binding helix [26]. Calcium binding to the low affinit...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... in the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by 50% in each case. In addition, these peptides also inhibit the activity of calcineurin, another enzyme ... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhibit t...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps
... recently pub- lished in HAE prophylaxis and therapy and these have led to the licensing of pdC1INH (Berinert ® ,CSLBehr- ing; Cinryze ® , ViroP harma; Ceto r-n ® , Sanquin) in many parts of the ... C1 INHIBITOR (C1INH) If “failing” on demand therapy with any of the angioedema event therapies (AERx’s; pdC1INH, rhC1INH, bradykinin B2 receptor antagonist, kallikrein inhibi...
Ngày tải lên: 08/08/2014, 21:20