Báo cáo y học: "Evolutionary rates and centrality in the yeast gene regulatory network" pdf

... Biology 2009, 10:R35 Open Access 2009Jovelin and PhillipsVolume 10, Issue 4, Article R35 Research Evolutionary rates and centrality in the yeast gene regulatory network Richard Jovelin and Patrick ... biological systems. Background Understanding of the function and evolution of any specific gene or protein requires knowledge of the context in which that gene o...

Ngày tải lên: 14/08/2014, 21:20

... placebo and epinephrine in VF cardiac arrest [30]. These seemingly contradictory findings may be explained by the fact that many of the studies do not take into account a subgroup analysis such as the ... vasodilation in the brain vessels. This results in an increase of the coronary perfusion pressure and, in general, an increase of blood flow to the vital organs withou...

Ngày tải lên: 13/08/2014, 08:21

Ngày tải lên: 13/08/2014, 01:20

... 'gain penalty' in the method proposed by Mirkin and coworkers [13]. We implemented the gain penalty in the same way. The ratio is not the same for individual genes and domains, and hence ... combinations include the SH2 domain, the protein-tyrosine phosphatase domain (Y_ phosphatase), and the phosphotyrosine interaction domain (PID), which are all relate...

Ngày tải lên: 14/08/2014, 07:21

... three forebrain areas, including the pallium, subpal- lium, and the diencephalon; the hind brain; and the spinal cord (our data do not include midbrain structures, and addi- tionally includes three ... according to the tissues in which they are highly expressed, with genes expressed in the brain evolving at significantly slower rates than those expressed in other tis...

Ngày tải lên: 14/08/2014, 21:20

... for theorizing that M/MΦ may contribute to the ongoing persistence of HIV-1 in these sites [11]. Monocyte trafficking to the CNS is hypothesized to be an underlying event in neuropathogenesis ... for these tests. Viral sub- types were determined by ELISA serotyping using V3-CM237 (Thai subtype B) and V3 CM242 (subtype E) peptides, which distinguishes HIV-1 subtype B and E in...

Ngày tải lên: 31/10/2012, 15:34

... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy...

Ngày tải lên: 31/10/2012, 17:11

... place, possibly interfering with the net de novo synthesis capacity of PtdIns synthase, especially if the membranes used as a source of enzyme are rich in PtdIns. Another question is the reason why CMP ... followed by synthesis is puzzling or in any case very difficult to analyse in terms of kinetics. From a functional point of view, if a reaction reverse of synthesis followed by s...

Ngày tải lên: 22/02/2014, 04:20

... adjacent to the beginning and the end of ybdQ and additional 20-nucleotide complementary to the template plasmid pKD13 carrying the kanamycin resistance (kan) gene. The resulted linear 1.4-kb ... extract by affinity chromatography using His-bind resin (Novagen), according to the manufacturer’s instructions. The protein was eluted with buffer K containing 1 M imidazole and...

Ngày tải lên: 22/02/2014, 07:20

... Among these motifs, the first histidine residue of motif 1 (DXHXH) is considered to be involved in the catalytic site of the enzyme and the second histidine residue may play a role in maintaining the ... remained. The N-D-AAase had higher hydrolysing activity against N-ace- tyl- D -amino acid derivates containing D -methionine, D -leucine and D -alanine and against N-chlo...

Ngày tải lên: 08/03/2014, 16:20