Báo cáo y học: "Evolving proteins at Darwin''''''''s bicentenary" docx

... relative trade-off between substrate specificity and enzymatic activity has given rise to a quasi-species-like evolutionary scenario: abundant protein polymorphisms underlie a complex population ... biological systems. CCoommppaarraattiivvee eevvoolluuttiioonn The primacy of comparative, and thus evolutionary, arguments in the analysis of proteins and their structure was emphasized by Tom B...

Ngày tải lên: 14/08/2014, 21:20

... Biochem Soc Symp. 1995, 61: 1-31 7. Touyz RM. Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology. Antioxid. ... expression and localization is critical with respect to damage, mutation and finally killing of eukaryotic cells. We found evidence that the KRED’s cytotoxicity is ascendantly location-dependent...

Ngày tải lên: 26/10/2012, 09:48

... regulatory activity and that a variety of nuclear transcription factors interact specifically with MREa [11,33,38,39]. These findings suggest that transcrip- tional activator proteins that regulate ... Dvir,A.,Peterson,S.R.,Knuth,M.W.,Lu,H.&Dynan,W.S. (1992) Ku autoantigen is the regulatory component of a template- associated protein kinase that phosphorylates RNA polymerase II. Proc. Nat...

Ngày tải lên: 17/03/2014, 23:20

... 5¢-GAATTCATGCATCCCTTCTACACC-3¢ (TobF) 5¢-GTCGACTTAGTTAGCCATAACAGGC-3¢ (TobR) (59–345) 5¢-GAATTCCACATAGGGGAGAAAGTG-3¢ TobR (84–345) 5¢-GAATTCGGCAATCTGCCACAGGAT-3¢ TobR (114–345) 5¢-GAATTCGTGGATGATAATAATGAA-3¢ TobR (1–315) TobF 5¢-GTCGACTTAGCCTCCATAGGCTGC-3¢ (1–277) ... cell cycle-dependent degradation of BTG/Tob family proteins, it is possible that phosphorylation is a signal for this degrada...

Ngày tải lên: 31/03/2014, 21:21

... and subsequent activation of intracellular PAD [11,15–18]. Alternatively, PAD enzymes may leak out of the dying cells, become activated (the extracellular calcium concentration is approximately 10 –3 mol/l, ... PAD enzymes may become activated by raised intracellular calcium levels, as probably is the case during the terminal differentiation of keratinocytes [20], a process that exhibits many...

Ngày tải lên: 09/08/2014, 01:23

... citrullinated proteins and the enzyme PAD4 are correlated with severity of inflammation and are not detect- able in healthy joints. The study also reveals that the citrull- ination of proteins ... pathogenesis. The targeted epitopes are generated by a post-translational modification catalysed by the calcium- dependent enzyme peptidyl arginine deiminase (PAD), which converts positively ......

Ngày tải lên: 09/08/2014, 06:22

... according to primary CTD diagnosis Unexplained polyarthritis 0/1 (0%) 0/1 (0%) Systemic sclerosis 1/10 (10%) 0/10 (0%) Systemic lupus erythematosus 0/1 (0%) 0/0 (0%) Polymyositis/dermatomyositis 1/13 ... previously diagnosed with paraproteinemia (Group 6) Age (years) Connective tissue disease Silicone implant Serum paraprotein (concentration and isotype) a Type Duration (years) Type Duratio...

Ngày tải lên: 09/08/2014, 10:21

... highly dynamic protein complexes can be modulated by post- translational modifications. NMR experiments with the cystic fibrosis transmembrane regulator (CFTR) indicate that the regulatory region ... virtually all proteins, a major goal is to understand the dynamics of two types of proteins that have critical roles in many human diseases: intrinsically disordered proteins, and prote...

Ngày tải lên: 09/08/2014, 20:20

... calculated death rates as deaths per 100 person-years of observation (PYO) and the tuberculosis incidence rates as number of tuberculosis cases per 100 PYO. All patients were considered to be at ... improve the treatment routines. Particular attention should be on the early weeks of treatment when mortality is high. Unfortu- nately, many of our patients had advanced disease at time of dia...

Ngày tải lên: 10/08/2014, 05:20

... am- midnight every day. The screening staff was made up of extensively trained undergraduate health sciences students. Patients that were not critically ill, whether they were ambulatory patients or ... participate in the study and then ran- domized to receive rapid HIV testing in the ED by a dedicated HIV counsellor or by a staff member at the ED, all GWU patients between the ages of 13 an...

Ngày tải lên: 10/08/2014, 05:21