Báo cáo y học: " From transcription start site to cell biology" ppt

... that transcription is regulated. This is made abundantly clear by the study from the FANTOM Consortium and the Riken Omics Science Center [11], which modeled the transcriptional regulatory networks ... general question: what is the complexity of polypeptides made in human cells, given the apparently high transcriptional complexity of RNAs made from a protein-coding locus? Analysis of av...

Ngày tải lên: 14/08/2014, 21:20

... tumor cell biology. (a) In normal cells, the role of IDH1 and IDH2 enzymes is to convert isocitrate to α-ketoglutarate (α-KG), converting NADP+ to NADPH. The presence of α-KG regulates prolylhydroxylases ... and because α-KG is required by prolyl hydroxy- lases, enzymes that hydroxylate and promote the degra- dation of hypoxia-inducible factor 1α (HIF-1α), the intra- cellular levels o...

Ngày tải lên: 09/08/2014, 20:21

... study are enticing, several issues with the study design will need to be addressed when future investigators examine this issue. A classic case–control methodology should ideally be employed, ... Using estimates from direct and indirect charges, Seymour and colleagues found that total hospital costs increased by an average of nearly $34,000 for reintubated patients. Although the results o...

Ngày tải lên: 12/08/2014, 20:20

... previous study, two regions in the soybean genome com- prising approximately 0.5 Mb each surrounding the soybean cyst nematode resistance loci, rhg1 and Rhg4, were used to identify syntenic regions ... were referred to as synteny blocks 1a, 1b, and 2 [32]. The syntenic regions in barrel medic also totaled about 1 Mb, though they were scattered into smaller contigs. For example, synteny bl...

Ngày tải lên: 14/08/2014, 08:20

... development is often directed by the action of factors with extremely narrow cell- type specificity. Since appropriate genetic circuitry models are likely to depend upon cell- specific, or at least ... individually by brassinosteroid and auxin; for these genes, the two hormones appeared to act synergistically. Additionally, Nemhauser et al. [5] assayed transcriptional responses to br...

Ngày tải lên: 14/08/2014, 14:21

... mediates Myc autorepression and its tran- scriptional control at many loci. In this study the authors used the Gal4 UAS system to express ectopic dmyc in embryos and performed microarray analysis to ... cuticle hydrolase activity transferase activity ion transporter activity carrier activity structural constituent of cytoeskeleton microtubule motor activity nucleoside binding hydrolase ac...

Ngày tải lên: 14/08/2014, 20:22

... accuracy to fall off rapidly for CSDeconv. Motif occurrence can be used not only to validate binding sites, but potentially also to find them. It may be possible to avoid blind deconvolution by simply ... distinct sites are separated by only 57 bp. That bind- ing occurs at both of these sites was previously established by mobility shift assays [16], and the relative contribu- tions of...

Ngày tải lên: 09/08/2014, 20:21

... may be applied to any arbitrary network topology, whereas the present E. coli network was chosen specifically to meet the NCA compatibility criteria [9]. As can be seen already from the few examples ... (top row) of four well-known cell- cycle transcription factors from the Spellman data compared to the respective gene expression measurements (bottom row)Figure 4 Time profiles of...

Ngày tải lên: 13/08/2014, 23:20

... batrachotoxin allosterically affects receptor site- 3 by shifting it from the l ow t o the high affinity state, increasing both scorpion a-toxin affinity and receptor site capacity [20,21,28]. Together ... further support from the 1.9-fold increase in receptor site capacity for scorpion a-toxins b inding in the p resence of b atrachotoxin, an alkaloid toxin binding to receptor site-...

Ngày tải lên: 08/03/2014, 16:20

... factor in the regulation of WD promoter activity. Comparison of WD promoter activity in Ku-deficient Xrs-5 cells to the activity in CHO cells To verify that Ku-80 is an essential regulatory factor ... able to confer a completely negative effect on WD gene promoter activity. It remains to be elucidated why WD promoter activity in Ku-80-expressing Xrs5 cells was not restored completely...

Ngày tải lên: 17/03/2014, 23:20