Báo cáo y học: "Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions" doc

... of how different subsystems interact within the Ub-system and develop an understanding of the diversification of the biochemistry of paralogous and functionally analogous components of the system. ... three enzyme cascade, namely E1, E2 and E3. Of these, the E1 enzyme usually catalyzes two reactions - ATP-dependent ade- nylation of the carboxylate followed...

Ngày tải lên: 14/08/2014, 21:20

... particu- larly during neck flexion. Based on the suspicious images of the spinous processes of the C7 and D1 vertebrae in the X-rays of the cervical and dorsal vertebrae (Figure 1), cer- vicodorsal ... femoral neck T-score was -2 .1. The patient was given 10 mg oral alendronate once a day. At the second month of follow-up, the control dual energy X- ray absorpti...

Ngày tải lên: 11/08/2014, 23:21

... LEF-1 and HEL with the yeast two- hybrid system had also been observed by Evans et al. (1999) [28]. Results from other coprecipitation studies supported the yeast two-hybrid results with the ... In addition, the yeast two-hybrid and coprecipitation studies demonstrated that LEF-3 interacts with both DNApol and HEL. The ability of LEF-3 to bind nonspecifically to singl...

Ngày tải lên: 23/03/2014, 21:20

... involving as many as 14 distinct signaling pathways, including the NF-κB pathway. Interestingly, many of the genes in these pathways are regulated by the proteasome [18]. Therefore, combined with our ... hence, ubiquitin- mediated proteolysis (Figure 1). Velcade is thought to block the activation of NF-κB and thereby deprive MM cells of the signals that are otherwise cons...

Ngày tải lên: 13/08/2014, 16:21

... the property of self- renewal. Second, when introduced into a host blastocyst they contribute to all tissues and even the germ cells of the result- ing chimeric animal: they have the property ... property of pluripotency. These features have been exploited in studies of early devel- opment and for the generation of genetically engineered mice [1]. Recently, the pluri...

Ngày tải lên: 14/08/2014, 17:22

... unpublished results), and the nucleosomes at the regulatory sites of the myogenin and MCK genes, which are bound by MyoD and MEF-2 family members, shift from a hypo- to a hyper-acteylated state during ... either directly or indirectly, the core myogenic regulators induce modifica- tions of the local chromatin infrastructure through recruit- ment of HAT- and possibly HD...

Ngày tải lên: 31/03/2014, 21:21

Ngày tải lên: 09/08/2014, 14:22

... [16,17] and cytologic simi- larity with b enign tumors and with the normal acinar component of the salivary gland, respectively. Fine-needle aspiration biopsy (FNAB) has been well established in the ... epithe- lial salivary neoplasm of a ductal cell origin. It is a low- grade malignancy that most often occurs in the parotid gland and presents at a relatively younger age...

Ngày tải lên: 11/08/2014, 00:22

... Radiology, Faculty of Medicine, Chiang Mai University, Suthep Road, Chiang Mai TH-50200, Thailand. 3 Department of Pathology, Faculty of Medicine, Chiang-Mai University, Suthep Road, Chiang Mai TH-50200, ... finding of a low-grade osteosarcoma simi- lartotheprimarylesionwitha50%necroticareaasa result of neoadjuvant chemotherapy, and the surgical mar- gin was free from tumor. Sev...

Ngày tải lên: 11/08/2014, 00:22

... - (0) + + + - + - + + /-* - (?) 8. Head- and neck cancer + (7) + + + + + - + - - (?) 9. Hematuria + (2) + + - - + - + . - (?) 10. Lung cancer + (2) + - + - + /- Three-stop-shop + + - (?) 11. Oesophageal atresia (children) - ... n.a. + + - n.a. + - - (?) 2. Breast cancer - (0) + + - - - Already implemented +...

Ngày tải lên: 11/08/2014, 05:21