Báo cáo y học: " Integrated analysis of breast cancer cell lines reveals unique signaling pathways" pot

... Gray JW: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006, 10:515-527. http://genomebiology.com/2009/10/3/R31 Genome Biology 2009, ... utility of symbolic systems modeling for the identification of key cell signaling events in the context of cancer. Materials and methods Cell lines The complete...

Ngày tải lên: 14/08/2014, 21:20

... 5 genes[35].Thediversityandabundance of miRNAtargetsreflectthatmiRNAsandtheir targetsappeartoformacomplexregulatorynetwork.Forexample,asinglemiRNAcan regulatehundreds of mRNAsandasinglemRNAcanbetargetedbyseveraldifferent miRNAs.  Basedonitsbiochemicalfunction,thebiologicalfunctions of amiRNAshoulddepend onthecombination of itsactiontoea...

Ngày tải lên: 14/08/2014, 16:20

... CP: Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. PLoS Comput Biol 2006, 2:e133. 23. Zhang Z, Harrison PM, Liu Y, Gerstein M: Millions of years of ... The large family of RP processed pseudogenes and the availability of whole genome sequences of many organisms allow us to perform a comprehensive and systematic comparative analysis...

Ngày tải lên: 14/08/2014, 21:20

... induction of c-Myc and cyclin D 1 , proteins required for cell cycle progression, but also via inhibition of the pro-apoptotic effects of c-Myc. Because c-Myc is highly expressed in RA synovium ... Th type 1 (Th1) or type 2 (Th2) cells, but now also includes Th17 cells (for review [88]). Th1 cells are primarily responsible for cell- mediated immunity and Th2 cells for humoral immunit...

Ngày tải lên: 09/08/2014, 10:23

... Access Research Cost analysis of an integrated disease surveillance and response system: case of Burkina Faso, Eritrea, and Mali ZanaCSomda* 1 , Martin I Meltzer 1 , Helen N Perry 1 , Nancy E Messonnier 1 , ... necessarily represent the views of the Centers for Disease Control and Additional file 1 Appendix _ Cost Analysis of IDSR. Appendix 1. List of IDSR priority dis- ease...

Ngày tải lên: 13/08/2014, 11:22

... hours of in- cubation, the cell pellets were collected for analysis. The intracellular location of the Bag-1 Morpho/AS was confirmed by fluorescent microscopy. Cell viability assay Cell viability ... to identify key molecules in the course of hy- poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into the mecha...

Ngày tải lên: 31/10/2012, 15:12

... of hCDC4 can also be observed in Acute Myeloid Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). Therefore we carried out a mutational analysis of the hCDC4 gene in 35 samples of ... Results Mutational analysis of hCDC4 in AML In this study the common exons 2 to 11 and the three known transcript variants of exon 1 of hCDC4 (Figure 1A) were analyzed by direct...

Ngày tải lên: 31/10/2012, 16:49

... levels of many of these genes identified in the array analysis. Moreover, Western blot analysis of thymo- cyte lysates also confirmed that IgM increases with age (Figure 3). Flow cytometry analysis ... A) CD138 analysis by flow cytometry demonstrates that there is no difference in the percentages of plasma cells in thymocytes from young and old mice. Averages of CD138...

Ngày tải lên: 03/11/2012, 11:35

... present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64. Cytotoxicity was analyzed in vitro using C2C12 skeletal muscle cells. Toxins (15 lg) ... potentiated by enzymatic degradation of phospholipids [7,44]. The capacity of DM64 to inhibit the myotoxicity induced by myotoxins I (Asp49) and II (Lys49) from B. asper venom was ana...

Ngày tải lên: 21/02/2014, 01:21

... lLof4· SDS polyacrylamide gel treatment buffer. Twenty microliters of each sample was then electrophoresed in 12.5% SDS polyacrylamide gels, blotted to nitrocellulose and probed with antibody ... H.S., Han, Y. & Fung, B.K K. (2000) Subunit e xchange of small h eat sho ck proteins. Analysis of olig- omer formation of aA-crystallin and Hsp27 by fluorescence res- onance energy tran...

Ngày tải lên: 22/02/2014, 04:20